Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 14/20 | 0.66 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10070377 | 0.91 | ROCK2 (0.63) | ROCK2TP53MAPTPOLB | |
| SCHEMBL10070035 | 0.88 | ROCK2 (0.84) | ROCK2TP53MAPT | |
| SCHEMBL10070034 | 0.85 | ROCK2 (0.83) | ROCK2 | |
| SCHEMBL321408 | 0.85 | ROCK2 (0.76) | ROCK2 | |
| SCHEMBL321409 | 0.85 | ROCK2 (0.76) | ROCK2 | |
| SCHEMBL10070393 | 0.84 | ROCK2 (0.85) | ROCK2 | |
| SCHEMBL320301 | 0.83 | ROCK2 (0.75) | ROCK2 | |
| SCHEMBL320300 | 0.83 | ROCK2 (0.75) | ROCK2 | |
| SCHEMBL10070397 | 0.82 | ROCK2 (0.85) | ROCK2MAPT | |
| SCHEMBL10069830 | 0.82 | ROCK2 (0.85) | ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012006202-A1 | RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-01-12 | — | — | WO | disclosed |