Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.55 |
| ▸ | WNT3A | P56704 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1007145 | 0.88 | HPGD (0.55) | HDAC6RAB9AALDH1A1HPGDKDM4E | |
| SCHEMBL30265383 | 0.84 | HDAC6 (0.55) | HDAC6RAB9AALDH1A1HPGDKDM4E | |
| SCHEMBL4961972 | 0.83 | HDAC6 (0.60) | HDAC6RAB9AALDH1A1HPGDKDM4E | |
| SCHEMBL17802748 | 0.81 | HDAC6 (0.55) | HDAC6RAB9AALDH1A1HPGDKDM4E | |
| SCHEMBL30265092 | 0.81 | HDAC6 (0.57) | HDAC6RAB9AALDH1A1HPGDKDM4E | |
| SCHEMBL30265374 | 0.80 | HTT (0.60) | HDAC6RAB9AALDH1A1KDM4EHTT | |
| SCHEMBL12094848 | 0.80 | CTNNB1 (0.67) | HDAC6RAB9AALDH1A1HPGDKDM4E | |
| Alcohol SCHEMBL28171577 | 0.79 | RAB9A (0.61) | HDAC6RAB9AALDH1A1HPGDKDM4E | |
| SCHEMBL3727881 | 0.78 | HDAC6 (0.58) | HDAC6RAB9AALDH1A1HPGDKDM4E | |
| SCHEMBL1534631 | 0.78 | HDAC6 (0.55) | HDAC6RAB9AALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268273-A1 | SMALL-MOLECULE MODULATORS OF TRP-P8 ACTIVITY | DENDREON CORPORATION (US) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009067410-A1 | SMALL-MOLECULE MODULATORS OF TRP-P8 ACTIVITY | DENDREON CORPORATION (US) | 2009-05-28 | — | — | WO | disclosed |