Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 9/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 2/20 | 0.31 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.30 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10071820 | 0.93 | EPHX2 (0.33) | EPHX2P2RX7PIK3CABDKRB1DHODH | |
| SCHEMBL15460053 | 0.92 | OPRL1 (0.34) | P2RX7HDAC1 | |
| SCHEMBL16404413 | 0.90 | HDAC1 (0.31) | HDAC1CYP4F2CYP4A11FLT3 | |
| SCHEMBL10070731 | 0.90 | EPHX2 (0.38) | EPHX2P2RX7 | |
| SCHEMBL10065662 | 0.90 | CNR2 (0.34) | P2RX7 | |
| SCHEMBL10071822 | 0.90 | EPHX2 (0.34) | EPHX2P2RX7PIK3CABDKRB1CYP4F2 | |
| SCHEMBL10070760 | 0.89 | BDKRB1 (0.38) | EPHX2P2RX7PIK3CABDKRB1FLT3 | |
| SCHEMBL10070763 | 0.89 | EPHX2 (0.36) | EPHX2P2RX7PIK3CABDKRB1DHODH | |
| SCHEMBL10070606 | 0.89 | BDKRB1 (0.36) | EPHX2P2RX7PIK3CABDKRB1DHODH | |
| SCHEMBL11906030 | 0.88 | BDKRB1 (0.36) | EPHX2P2RX7PIK3CABDKRB1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2606042-B1 | DISUBSTITUTED TETRAHYDROFURANYL COMPOUNDS AS BRADYKININ B1 RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INT (DE) | 2014-09-03 | — | — | EP | disclosed |
| WO-2012022795-A1 | DISUBSTITUTED TETRAHYDOFURANYL COMPOUNDS AS ANTAGONISTS OF THE BRADYKININ B1 RECEPTOR | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-02-23 | — | — | WO | disclosed |