Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 5/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 2/20 | 0.31 |
| ▸ | FLT3 | P36888 | 2/20 | 0.31 |
| ▸ | TNKS | O95271 | 2/20 | 0.31 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.31 |
| ▸ | DHODH | Q02127 | 2/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10071821 | 0.93 | EPHX2 (0.34) | EPHX2P2RX7PIK3CABDKRB1FLT3 | |
| SCHEMBL10066086 | 0.91 | CNR2 (0.36) | P2RX7CNR2 | |
| SCHEMBL15460097 | 0.91 | ALOX15 (0.36) | P2RX7CNR2MAPK3 | |
| SCHEMBL10070762 | 0.90 | EPHX2 (0.37) | EPHX2P2RX7 | |
| SCHEMBL16404426 | 0.90 | FLT3 (0.31) | P2RX7CNR2FLT3TNKSTNKS2 | |
| SCHEMBL10071822 | 0.89 | EPHX2 (0.34) | EPHX2P2RX7PIK3CABDKRB1FLT3 | |
| SCHEMBL10070596 | 0.89 | BDKRB1 (0.36) | EPHX2P2RX7PIK3CABDKRB1CNR2 | |
| SCHEMBL10070759 | 0.89 | EPHX2 (0.34) | EPHX2P2RX7PIK3CABDKRB1CNR2 | |
| SCHEMBL10070760 | 0.89 | BDKRB1 (0.38) | EPHX2P2RX7PIK3CABDKRB1CNR2 | |
| SCHEMBL11906323 | 0.88 | BDKRB1 (0.36) | EPHX2P2RX7PIK3CABDKRB1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2606042-B1 | DISUBSTITUTED TETRAHYDROFURANYL COMPOUNDS AS BRADYKININ B1 RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INT (DE) | 2014-09-03 | — | — | EP | disclosed |
| WO-2012022795-A1 | DISUBSTITUTED TETRAHYDOFURANYL COMPOUNDS AS ANTAGONISTS OF THE BRADYKININ B1 RECEPTOR | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-02-23 | — | — | WO | disclosed |