Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14938561 | 0.81 | ALDH1A1 (0.59) | ALDH1A1MMP2SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL23253782 | 0.78 | ALDH1A1 (0.60) | ALDH1A1MMP2SMN1; SMN2KMT2AMEN1 | |
| Phenylmethylsemicarbazone SCHEMBL31006435 | 0.78 | ALDH1A1 (0.56) | ALDH1A1MMP2SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL11302626 | 0.77 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL17541218 | 0.77 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL11293827 | 0.75 | ALDH1A1 (0.69) | ALDH1A1MMP2SMN1; SMN2KMT2APOLB | |
| SCHEMBL28909466 | 0.74 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL14938457 | 0.73 | ALDH1A1 (0.51) | ALDH1A1MMP2SMN1; SMN2HTTPOLB | |
| SCHEMBL17666943 | 0.71 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2KMT2AHTTPOLB | |
| SCHEMBL17666941 | 0.71 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2KMT2AHTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8193192-B2 | Heterocyclic FXR binding compounds | PHENEX PHARMACEUTICALS AG (DE) | 2012-06-05 | — | — | US | disclosed |
| US-20100210660-A1 | Heterocyclic FXR Binding Compounds | PHENEX PHARMACEUTICALS AG (DE) | 2010-08-19 | — | — | US | disclosed |
| US-20100184809-A1 | Heterocyclic FXR Binding Compounds | PHENEX PHARMACEUTICALS AG (DE) | 2010-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100210660-A1 | Heterocyclic FXR Binding Compounds | NR1H4, NR1I3, NR1I2 | ALDH1A1 3529/4885MMP2 4696/4885SMN1; SMN2 4816/4885 |
| US-20100184809-A1 | Heterocyclic FXR Binding Compounds | NR1H4, NR1H2, NR1H3 | ALDH1A1 3095/4885MMP2 4825/4885SMN1; SMN2 4853/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.