⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12191315 | 0.84 | — | — | |
| SCHEMBL10072463 | 0.80 | LMNA (0.41) | — | |
| SCHEMBL13722197 | 0.79 | — | — | |
| SCHEMBL14946296 | 0.74 | — | — | |
| SCHEMBL18561543 | 0.74 | — | — | |
| SCHEMBL20250981 | 0.73 | CYP1A2 (0.30) | — | |
| SCHEMBL10072468 | 0.72 | P2RY6 (0.39) | — | |
| SCHEMBL10072462 | 0.72 | ABL1 (0.50) | — | |
| SCHEMBL26268507 | 0.70 | — | — | |
| SCHEMBL2718157 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130041144-A1 | 5'-SUBSTITUTED BICYCLIC NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM | ISIS PHARMACEUTICALS, INC. (US) | 2013-02-14 | — | — | US | disclosed |
| US-8268980-B2 | 5′-modified bicyclic nucleic acid analogs | ISIS PHARMACEUTICALS, INC. (US) | 2012-09-18 | — | — | US | disclosed |
| US-20120010393-A1 | 5'-MODIFIED BICYCLIC NUCLEIC ACID ANALOGS | ISIS PHARMACEUTICALS, INC. (US) | 2012-01-12 | — | — | US | disclosed |