LMNA

Prelamin-A/C · P02545 · LMNA on Sugi Atlas →

5,736,466 patent compounds predicted against LMNA, 3,058,459 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Tolnaftate (SCHEMBL3520)	1.00	6/20
Vinblastine (SCHEMBL3549)	1.00	6/20
Vinblastine (SCHEMBL3550)	1.00	6/20
Vinblastine (SCHEMBL3628)	1.00	6/20
Vinblastine (SCHEMBL3629)	1.00	6/20
Ampicillin (SCHEMBL3526)	0.98	6/20
Etoposide Phosphate (SCHEMBL3621)	0.83	6/20
Procaine (SCHEMBL3524)	0.68	6/20
Trioxsalen (SCHEMBL1252)	0.43	6/20
Megestrol Acetate (SCHEMBL745)	1.00	5/20
Mevastatin (SCHEMBL1116)	1.00	5/20
Miconazole (SCHEMBL2866)	1.00	5/20
(R)-Miconazole (SCHEMBL2867)	1.00	5/20
Ciprofloxacin (SCHEMBL2900)	1.00	5/20
Lovastatin (SCHEMBL3136)	1.00	5/20
Lovastatin (SCHEMBL3137)	1.00	5/20
Chloroxine (SCHEMBL3350)	1.00	5/20
Iodoquinol (SCHEMBL3460)	1.00	5/20
Norfloxacin (SCHEMBL3473)	1.00	5/20
Miconazole (SCHEMBL3366)	0.98	5/20

Clinical trials — most relevant to LMNA by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Lifestyle and Pharmacological Interventions in Hypertrophic Cardiomyopathy	PHASE2/PHASE3	COMPLETED
Treatment of Preclinical Hypertrophic Cardiomyopathy With Diltiazem	PHASE2/PHASE3	COMPLETED
Phase II Trial of Lonafarnib (a Farnesyltransferase Inhibitor) for Progeria	PHASE2	COMPLETED
Treatment of the Hutchinson-Gilford Progeria Syndrome With a Combination of Pravastatin and Zoledronic Acid	PHASE2	COMPLETED
A Study of ARRY-371797 in Patients With LMNA-Related Dilated Cardiomyopathy	PHASE2	COMPLETED
Study to Determine Optimal Dose and Evaluate Safety, Tolerability, and Pharmacokinetics of Progerinin in Patients With Hutchinson-Gilford Progeria Syndrome (HGPS)	PHASE2	ACTIVE_NOT_RECRUITING
Sacubitril/Valsartan vs Lifestyle in Hypertrophic Cardiomyopathy	PHASE2	COMPLETED
Phase I Study of Progerinin in Healthy Volunteers	PHASE1	COMPLETED
Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure	nan	RECRUITING
Cardiac Arrhythmias and Sudden Death in Patients Affected With Laminopathies	nan	UNKNOWN
NUCLEAR LAMINA, OVARIAN AGE AND MEDICAL ASSISTANCE TO PROCREATION	nan	UNKNOWN
Clinical and Genetic Examinations of Dilated Cardiomyopathy	nan	COMPLETED
Hearts in Rhythm Organization (HiRO)National Registry and Bio Bank	nan	ENROLLING_BY_INVITATION
The Deep Phenotype of Lamin A/C Cardiomyopathy	nan	UNKNOWN
Observatoire Des Patients Atteints de Laminopathies et Emerinopathies (Observatory for PAtients With Laminopathies and Emerinopathies)	nan	RECRUITING
LAMA2 Genetic Correction	nan	COMPLETED
Biomarkers in SCOTland CardiomyopatHy Registry (Bio-SCOTCH)	nan	RECRUITING
Lonafarnib for Patients With Hutchinson-Gilford Progeria Syndrome or Progeroid Laminopathy	nan	APPROVED_FOR_MARKETING
Natural History of Danon Disease	nan	COMPLETED
Evaluation of Genetic-molecular Causes of Out-of-Hospital Cardiac Arrest: From Patients to Families	nan	RECRUITING
Screening Patients With Fabry Disease in Patients With Hypertrophic Cardiomyopathy or Left Ventricular Hypertrophy	nan	UNKNOWN
Genetic Clues to Chordoma Etiology: A Protocol to Identify Sporadic Chordoma Patients for Studies of Cancer-Susceptibility Genes	nan	ACTIVE_NOT_RECRUITING
Long Term Monitoring for Risk of Sudden Death	nan	COMPLETED
Idiopathic Dilated Cardiomyopathy	nan	COMPLETED
Clinical Variability in Marfan Syndrome	nan	COMPLETED
Pediatric Cardiomyopathy Mutation Analysis	nan	RECRUITING
ASF Alport Patient Registry	nan	RECRUITING
Genetics of Neonatal Encephalopathy and Related Disorders	nan	RECRUITING
Dilated Cardiomyopathy-Cardiac Magnetic Resonance (DCM-CMR) Ancillary Study	nan	ACTIVE_NOT_RECRUITING
Predictive Factors and Consequences of Myocardial Fibrosis in Hypertrophic Cardiomyopathy	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a LMNA binder may also engage these)

Protein	Name	Similarity
P48678	—	1.000	P48678 →
Q3ZD69	—	1.000	Q3ZD69 →
P48679	—	1.000	P48679 →
P13648	—	1.000	P13648 →
P21619	—	1.000	P21619 →
P14732	—	1.000	P14732 →
P11048	—	0.998	P11048 →
P21910	—	0.997	P21910 →
LMNB2	Lamin-B2	0.995	landscape →
P09010	—	0.994	P09010 →
P10999	—	0.993	P10999 →
P14733	—	0.993	P14733 →
Q4R4X4	—	0.992	Q4R4X4 →
P48616	—	0.992	P48616 →
P48676	—	0.991	P48676 →
P15331	—	0.991	P15331 →
Q9Z320	—	0.991	Q9Z320 →
LMNB1	Lamin-B1	0.991	landscape →
P70615	—	0.990	P70615 →
P35617	—	0.990	P35617 →
P14731	—	0.990	P14731 →
P21807	—	0.989	P21807 →
Q92155	—	0.989	Q92155 →
P24789	—	0.989	P24789 →
Q03427	—	0.989	Q03427 →
A6QQJ3	—	0.989	A6QQJ3 →
P09654	—	0.989	P09654 →
Q7Z3Z0	—	0.989	Q7Z3Z0 →
P48674	—	0.988	P48674 →
P08928	—	0.988	P08928 →