Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 18/20 | 0.81 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.77 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.77 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.77 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.77 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.77 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.77 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.65 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.65 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.65 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.65 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.65 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.65 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.65 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.65 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.65 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.65 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.65 |
| ▸ | PSMB11 | A5LHX3 | 5/20 | 0.62 |
| ▸ | PSMD11 | O00231 | 5/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21652528 | 1.00 | PSMB5 (0.81) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21652546 | 1.00 | PSMB5 (0.81) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL17058764 | 1.00 | PSMB5 (0.81) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL15590903 | 1.00 | PSMB5 (0.81) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21652548 | 1.00 | PSMB5 (0.81) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL19871620 | 1.00 | PSMB5 (0.81) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| Hydrochloric Acid SCHEMBL30764680 | 0.99 | PSMB5 (0.80) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL25787921 | 0.92 | PSMB5 (0.71) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL25787740 | 0.91 | PSMB5 (0.81) | PSMB5PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21652545 | 0.91 | PSMB5 (0.69) | PSMB5PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11667654-B2 | Process for the preparation of boronic acid esters | FRESENIUS KABI ONCOLOGY LTD. (IN) | 2023-06-06 | — | — | US | disclosed |
| US-11667654-B2 | Process for the preparation of boronic acid esters | FRESENIUS KABI ONCOLOGY LTD. (IN) | 2023-06-06 | — | — | US | disclosed |
| US-20220204558-A1 | SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS | MILLENNIUM PHARM INC (US) | 2022-06-30 | — | — | US | disclosed |
| US-20210395301-A1 | SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS | MILLENNIUM PHARM INC (US) | 2021-12-23 | — | — | US | disclosed |
| EP-3385267-B1 | SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS | MILLENNIUM PHARM INC (US) | 2021-09-29 | — | — | EP | disclosed |
| US-20210171574-A1 | SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS | MILLENNIUM PHARM INC (US) | 2021-06-10 | — | — | US | disclosed |
| US-20200369722-A1 | SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS | MILLENNIUM PHARM INC (US) | 2020-11-26 | — | — | US | disclosed |
| US-20200157143-A1 | SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS | MILLENNIUM PHARM INC (US) | 2020-05-21 | — | — | US | disclosed |
| US-20190330270-A1 | SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS | MILLENNIUM PHARMACEUTICALS, INC. | 2019-10-31 | — | — | US | disclosed |
| US-20190112334-A1 | SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS | MILLENNIUM PHARMACEUTICALS, INC. | 2019-04-18 | — | — | US | disclosed |
| US-20130085277-A1 | PROCESS FOR THE PREPARATION OF BORTEZOMIB | RANBAXY LABORATORIES LIMITED (IN) | 2013-04-04 | — | — | US | disclosed |
| US-20130005968-A1 | SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-01-03 | — | — | US | disclosed |
| US-8283467-B2 | Synthesis of boronic ester and acid compounds | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-10-09 | — | — | US | disclosed |
| US-8283467-B2 | Synthesis of boronic ester and acid compounds | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-10-09 | — | — | US | disclosed |
| WO-2011098963-A9 | PROCESS FOR THE PREPARATION OF BORTEZOMIB | RANBAXY LABORATORIES LIMITED (IN) | 2012-01-26 | — | — | WO | disclosed |
| WO-2011098963-A1 | PROCESS FOR THE PREPARATION OF BORTEZOMIB | RANBAXY LABORATORIES LIMITED (IN) | 2011-08-18 | — | — | WO | disclosed |
| US-20100174072-A1 | SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | US | disclosed |
| US-20100174072-A1 | SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-07-08 | — | — | US | disclosed |
| US-7714159-B2 | contacting the boronate complex of formula with Lewis acid catalyst in presence of a coordinating ether solvent having low miscibililty in water | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-05-11 | — | — | US | disclosed |
| US-7714159-B2 | contacting the boronate complex of formula with Lewis acid catalyst in presence of a coordinating ether solvent having low miscibililty in water | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11667654-B2 | Process for the preparation of boronic acid esters | PBRM1, BET1, MALT1 | PSMB5 275/4885PSEN1 1031/4885PSEN2 2898/4885 |
| US-20220204558-A1 | SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS | BTD, BCL6, BRAP | PSMB5 17/4885PSEN1 1706/4885PSEN2 2259/4885 |
| US-20190330270-A1 | SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS | BTD, BCL6, BRAP | PSMB5 17/4885PSEN1 1706/4885PSEN2 2259/4885 |
| US-20210395301-A1 | SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS | BTD, BCL6, BRAP | PSMB5 17/4885PSEN1 1706/4885PSEN2 2259/4885 |
| US-20130005968-A1 | SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS | BTD, BCL6, BRAP | PSMB5 17/4885PSEN1 1706/4885PSEN2 2259/4885 |
| US-20100174072-A1 | SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS | BTD, BCL6, BRAP | PSMB5 17/4885PSEN1 1706/4885PSEN2 2259/4885 |
| US-20200157143-A1 | SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS | BTD, BCL6, BRAP | PSMB5 17/4885PSEN1 1706/4885PSEN2 2259/4885 |
| US-20190112334-A1 | SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS | BTD, BCL6, BRAP | PSMB5 17/4885PSEN1 1706/4885PSEN2 2259/4885 |
| US-20130085277-A1 | PROCESS FOR THE PREPARATION OF BORTEZOMIB | PSMB5, PSMB1, PSMC1 | PSMB5 1/4885PSEN1 216/4885PSEN2 547/4885 |
| US-20200369722-A1 | SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS | BTD, BCL6, BRAP | PSMB5 17/4885PSEN1 1706/4885PSEN2 2259/4885 |
| US-20210171574-A1 | SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS | BTD, BCL6, BRAP | PSMB5 17/4885PSEN1 1706/4885PSEN2 2259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.