PSMB1

Proteasome component C5 · P20618 · PSMB1 on Sugi Atlas →

46,415 patent compounds predicted against PSMB1, 30,984 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL605949 SCHEMBL605949 0.54 15/20
SCHEMBL606344 SCHEMBL606344 0.51 13/20
SCHEMBL464494 SCHEMBL464494 0.56 12/20
SCHEMBL607010 SCHEMBL607010 0.56 12/20
SCHEMBL464427 SCHEMBL464427 0.55 12/20
SCHEMBL606932 SCHEMBL606932 0.53 12/20
SCHEMBL606926 SCHEMBL606926 0.52 12/20
SCHEMBL464426 SCHEMBL464426 0.51 12/20
SCHEMBL606616 SCHEMBL606616 0.51 12/20
SCHEMBL607035 SCHEMBL607035 0.61 11/20
SCHEMBL605158 SCHEMBL605158 0.59 11/20
SCHEMBL606315 SCHEMBL606315 0.59 11/20
SCHEMBL464482 SCHEMBL464482 0.55 11/20
SCHEMBL606626 SCHEMBL606626 0.54 11/20
SCHEMBL464479 SCHEMBL464479 0.54 11/20
SCHEMBL605822 SCHEMBL605822 0.54 11/20
SCHEMBL606523 SCHEMBL606523 0.53 11/20
SCHEMBL605129 SCHEMBL605129 0.52 11/20
SCHEMBL606363 SCHEMBL606363 0.52 11/20
SCHEMBL464475 SCHEMBL464475 0.52 11/20

Clinical trials — most relevant to PSMB1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Patients With Crohn's Disease PHASE4UNKNOWN
Doxorubicin and Bortezomib in Treating Patients With Liver Cancer PHASE2COMPLETED
A Study of GSK2110183 in Subjects With Proteasome Inhibitor Refractory Multiple Myeloma PHASE2WITHDRAWN
A Study of the Safety and Efficacy of CNTO 328 and Bortezomib to Bortezomib Alone in Patients With Relapsed or Refractory Multiple Myeloma PHASE2COMPLETED
Tamoxifen and Bortezomib to Treat Recurrent Brain Tumors PHASE2COMPLETED
Desferal Administration to Improve the Impaired Reaction to Hypoxia in Diabetes PHASE2UNKNOWN
The Effect of Roxadustat on Renal Oxygenation in Diabetes Nephropathy PHASE2NOT_YET_RECRUITING
Bortezomib and Docetaxel in Treating Patients With Recurrent or Metastatic Head and Neck Cancer PHASE2COMPLETED
Trial to Evaluate Efficacy and Safety of Bortezomib in Patients With Severe Autoimmune Encephalitis PHASE2RECRUITING
Study of Patients With Stage IV Malignant Melanoma Using PS-341 (Bortezomib, Velcade) and Interferon-alpha-2b in Malignant Melanoma PHASE1COMPLETED
PS-341 and Radiation to Treat Advanced Cancer of the Head and Neck PHASE1COMPLETED
Study of Irinotecan and Bortezomib in Children With Recurrent/Refractory Neuroblastoma PHASE1COMPLETED
Extended Infusion Carfilzomib on a Weekly Schedule in Patients With Advanced Solid Tumors PHASE1COMPLETED
GO-203-2C + Bortezomib For Relapsed Or Refractory MM PHASE1WITHDRAWN
A Phase I Study Of Thymoglobulin In Patients With Relapsed Or Refractory Multiple Myeloma PHASE1COMPLETED
Bortezomib, Fluorouracil, and Leucovorin Calcium in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed By Surgery PHASE1COMPLETED
Study of Marizomib With Temozolomide and Radiotherapy in Patients With Newly Diagnosed Brain Cancer PHASE1COMPLETED
Bortezomib and Carboplatin in Treating Patients With Recurrent or Progressive Ovarian Epithelial, Primary Peritoneal, or Fallopian Tube Cancer PHASE1COMPLETED
Characterization of the Changes in the Signalling Pathways During Spinal Cord Injury-induced Skeletal Muscle Atrophy nanUNKNOWN
Evaluation of Proteasome as a Marker of Hepatocellular Carcinoma in Cirrhotic Patients Following Curative Treatment nanUNKNOWN
Cardiovascular Complications of Carfilzomib Treatment nanUNKNOWN
Low Dose Melphalan and Bortezomib for AML and High-Risk MDS nanCOMPLETED
The Pathophysiology of Bortezomib Induced Peripheral Neuropathy nanUNKNOWN
The PREServation of MUScle Function in Critically Ill Patients (PRESMUS) nanUNKNOWN
Clinical Study of 68Ga-DOTA-BLP PET Imaging in Noninvasive Diagnosis of Malignant Tumors nanNOT_YET_RECRUITING
Safety and Tolerability of a Nutritional Formula Designed to Aid in Maintenance of Muscle During Periods of Caloric Restriction in Adults nanNOT_YET_RECRUITING
Impact of O6-methylguanine-DNA Methyltransferase (MGMT) Promoter Methylation and MGMT Expression on Dacarbazine Treated Sarcoma Patients (MGMT) nanUNKNOWN
Mitochondrial Activity and Myosteatosis in the Cachexia of Cancers of the Upper Aerodigestive Tract nanUNKNOWN
Establishment of Human Cellular Disease Models for Wilson Disease nanCOMPLETED
Inhibition of SENP1 for the Suppression of OS Growth and Metastasis nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a PSMB1 binder may also engage these)

ProteinNameSimilarity
P18421 1.000 P18421 →
Q2TBX6 1.000 Q2TBX6 →
O09061 1.000 O09061 →
Q9IB83 0.999 Q9IB83 →
Q9IB84 0.997 Q9IB84 →
Q6DRF3 0.996 Q6DRF3 →
P28024 0.978 P28024 →
Q9P6U7 0.972 Q9P6U7 →
Q7DLR9 0.970 Q7DLR9 →
P99026 0.969 P99026 →
O23714 0.969 O23714 →
P34067 0.968 P34067 →
P40307 0.968 P40307 →
Q3T108 0.966 Q3T108 →
PSMB2 Proteasome Macropain subunit 0.966 landscape →
Q5E9K0 0.964 Q5E9K0 →
Q9R1P3 0.964 Q9R1P3 →
PSMB4 Proteasome subunit beta type-4 0.963 landscape →
O24633 0.960 O24633 →
Q9LST6 0.951 Q9LST6 →
Q9XG77 0.944 Q9XG77 →
Q2RAK2 0.943 Q2RAK2 →
B6JAL5 0.942 B6JAL5 →
O80526 0.942 O80526 →
Q01217 0.941 Q01217 →
Q89WM9 0.941 Q89WM9 →
Q9D753 0.940 Q9D753 →
Q2QXR8 0.940 Q2QXR8 →
Q2QZ86 0.940 Q2QZ86 →
B8BM17 0.940 B8BM17 →