Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | GCK | P35557 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11400978 | 0.77 | HPGD (0.54) | ALDH1A1HPGDKMT2AMEN1HSP90AA1 | |
| SCHEMBL4207122 | 0.77 | KMT2A (0.53) | ALDH1A1PTGES2HPGDKMT2AMEN1 | |
| SCHEMBL23093222 | 0.76 | NSD2 (0.44) | ALDH1A1HPGDKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL23718180 | 0.73 | ALDH1A1 (0.39) | ALDH1A1CASP6GCKSMN1; SMN2L3MBTL1 | |
| SCHEMBL4638550 | 0.68 | MAPT (0.47) | ALDH1A1KMT2AMEN1HTTSMN1; SMN2 | |
| SCHEMBL1863910 | 0.65 | CYP2D6 (0.62) | ALDH1A1HPGDKMT2AMEN1GAA | |
| SCHEMBL21017043 | 0.63 | LOX (0.68) | ALDH1A1CYP1A2HPGDKMT2AHTT | |
| SCHEMBL3079941 | 0.63 | — | — | |
| SCHEMBL1706125 | 0.63 | SMN1; SMN2 (0.59) | ALDH1A1CYP1A2KMT2AMEN1CASP6 | |
| SCHEMBL6261295 | 0.63 | PTGES2 (0.53) | ALDH1A1CYP1A2PTGES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951254-B1 | [4-(6-HALO-7-SUBSTITUTED-2,4-DIOXO-1,4-DIHYDRO-2H-QUINAZOLIN-3-YL)-PHENYL]-5-CHLORO-THIOPHEN-2-YL-SULFONYLUREAS AND FORMS AND METHODS RELATED THERETO | PORTOLA PHARM INC (US) | 2012-01-04 | — | — | EP | disclosed |