⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24161976 | 0.78 | — | — | |
| SCHEMBL19369772 | 0.78 | — | — | |
| SCHEMBL10049271 | 0.78 | — | — | |
| SCHEMBL12788513 | 0.75 | — | — | |
| SCHEMBL8278625 | 0.65 | CHRNB2 (0.31) | — | |
| SCHEMBL18069367 | 0.64 | — | — | |
| SCHEMBL24378363 | 0.60 | SMN1; SMN2 (0.37) | — | |
| SCHEMBL11890818 | 0.60 | — | — | |
| SCHEMBL14597372 | 0.60 | — | — | |
| SCHEMBL15699348 | 0.59 | HTR2A (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140162943-A1 | N-TERMINUS CONFORMATIONALLY CONSTRAINED GLP-1 RECEPTOR AGONIST COMPOUNDS | ASTRAZENECA PHARMACEUTICALS, LP (US) | 2014-06-12 | — | — | US | disclosed |
| US-8642544-B2 | N-terminus conformationally constrained GLP-1 receptor agonist compounds | AMYLIN PHARMACEUTICALS, LLC (US) | 2014-02-04 | — | — | US | disclosed |
| US-20120046222-A1 | N-TERMINUS CONFORMATIONALLY CONSTRAINED GLP-1 RECEPTOR AGONIST COMPOUNDS | AMYLIN PHARMACEUTICALS, INC. (US) | 2012-02-23 | — | — | US | disclosed |
| WO-2010120476-A2 | N-TERMINUS CONFORMATIONALLY CONSTRAINED GLP-1 RECEPTOR AGONIST COMPOUNDS | AMYLIN PHARMACEUTICALS, INC. (US) | 2010-10-21 | — | — | WO | disclosed |