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CHRNB2

Neuronal acetylcholine receptor subunit beta-2 · P17787 · CHRNB2 on Sugi Atlas →

187,442 patent compounds predicted against CHRNB2, 85,080 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Radafaxine Radafaxine (SCHEMBL48964) 1.00 20/20
SCHEMBL80066 SCHEMBL80066 0.65 12/20
Bromide Bromide (SCHEMBL69311) 0.62 11/20
Dl-Anabasine Dl-Anabasine (SCHEMBL117530) 1.00 10/20
Varenicline Varenicline (SCHEMBL137144) 1.00 10/20
SCHEMBL80814 SCHEMBL80814 0.72 10/20
Nornicotine Nornicotine (SCHEMBL158145) 1.00 9/20
Nornicotine Nornicotine (SCHEMBL158146) 1.00 9/20
SCHEMBL137900 SCHEMBL137900 0.59 9/20
SCHEMBL159642 SCHEMBL159642 1.00 8/20
SCHEMBL5335 SCHEMBL5335 0.87 8/20
SCHEMBL100931 SCHEMBL100931 0.60 8/20
SCHEMBL80826 SCHEMBL80826 0.58 8/20
SCHEMBL81218 SCHEMBL81218 0.53 8/20
SCHEMBL81293 SCHEMBL81293 0.51 8/20
SCHEMBL105590 SCHEMBL105590 0.51 8/20
SCHEMBL157893 SCHEMBL157893 0.51 8/20
SCHEMBL52844 SCHEMBL52844 0.69 7/20
SCHEMBL155343 SCHEMBL155343 0.65 7/20
SCHEMBL155974 SCHEMBL155974 0.65 7/20

Clinical trials — most relevant to CHRNB2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Efficacy of the Use of Genetic Markers in the Choice of the Pharmacological Treatment of Smoking (GENTSMOKING) PHASE4COMPLETED
Dexmedetomidine Effect on Delirium of Elderly Patients PHASE4UNKNOWN
Galantamine for Cognition in People With Schizophrenia PHASE4COMPLETED
Efficacy Study of Galantamine for Cognitive Impairments in Schizophrenia PHASE4COMPLETED
Transcranial Magnetic Stimulation in Patients with Dual Disorders PHASE3NOT_YET_RECRUITING
Cholinergic Mechanisms of Gait Dysfunction in Parkinson's Disease Experiments 1 & 2 - Proj #3 PHASE2COMPLETED
Crossover Target Engagement Study of Cholinergic Mechanisms of Gait Dysfunction in Parkinson's Disease (Project #3 - Experiment 3 [UdallP3E3]) PHASE2COMPLETED
Cholinergic Integrity in Down Syndrome in Association With Aging, Alzheimer's Disease Pathology, and Cognition PHASE2RECRUITING
Social Cognition,Attentional Network and Nicotine Drug Dependency - A Pharmacological Clinical Trail PHASE1/PHASE2COMPLETED
Effect of Varenicline on Cognitive Function in Cigarette Smokers With Schizophrenia PHASE2COMPLETED
Nicotinic Receptors and Schizophrenia PHASE1/PHASE2WITHDRAWN
Brain Networks and Addiction Susceptibility PHASE1COMPLETED
Nicotinic Receptor Genetic Variation and Alcohol Reward PHASE1RECRUITING
Gene Therapy for Alzheimer's Disease Clinical Trial PHASE1COMPLETED
Common Noradrenergic Mechanisms in Parkinson´s Disease and L-DOPA Induced Dyskinesia nanUNKNOWN
The Locus Coeruleus, Norepinephrine and Cognitive Aging nanACTIVE_NOT_RECRUITING
Copy Number Variation in CHRNA7 Gene in Migraine and Gene Expression nanCOMPLETED
Nicotinic Receptor Levels After Stopping Smoking nanCOMPLETED
fMRI Study of Nicotinic Effect on Neurophysiology of Schizophrenia nanCOMPLETED
Brain Imaging in Alzheimer's Disease nanCOMPLETED
Effects of Prazosin on the Attention-Enhancing Effects of Nicotine nanWITHDRAWN
Single Photon Emission Computed Tomography to Study Receptors in Parkinson's Disease nanCOMPLETED
Neural Inhibition as a Mechanism of Nicotine Dependence Among Persons With Schizophrenia nanCOMPLETED
Brain Receptors in Sympathetic Nervous System Regulation nanCOMPLETED
The Genetic Characterization of Dementia nanCOMPLETED
Non-Invasive Brain Stimulation to Improve Language in Down Syndrome. nanRECRUITING
Nicotinic Receptor Density in Smoking and Nonsmoking Schizophrenics nanWITHDRAWN
Immunoadsorption Study Mainz in Adults With Post-COVID Syndrome nanCOMPLETED
Reversal of Neuromuscular Blockade in Thoracic Surgical Patients nanCOMPLETED
A Study on Risk Mutations of Vulnerability Genes of Schizophrenia nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a CHRNB2 binder may also engage these)

ProteinNameSimilarity
P09484 — 1.000 P09484 →
Q9ERK7 — 1.000 Q9ERK7 →
P12390 — 1.000 P12390 →
P12392 — 0.995 P12392 →
Q8SPU6 — 0.994 Q8SPU6 →
P19370 — 0.993 P19370 →
Q8R493 — 0.991 Q8R493 →
P91766 — 0.990 P91766 →
CHRNB4 Neuronal acetylcholine receptor subunit beta- 0.990 landscape →
CHRNA6 Neuronal acetylcholine receptor subunit alpha 0.989 landscape →
CHRNA2 Neuronal acetylcholine receptor subunit alpha 0.989 landscape →
Q91X60 — 0.989 Q91X60 →
P49579 — 0.988 P49579 →
P26153 — 0.988 P26153 →
P02716 — 0.988 P02716 →
P49580 — 0.987 P49580 →
P25110 — 0.987 P25110 →
Q5IS52 — 0.987 Q5IS52 →
Q9N587 — 0.987 Q9N587 →
Q5IS51 — 0.987 Q5IS51 →
Q8R4G9 — 0.986 Q8R4G9 →
P02712 — 0.986 P02712 →
P04759 — 0.986 P04759 →
P12389 — 0.986 P12389 →
P04757 — 0.985 P04757 →
P05376 — 0.985 P05376 →
P09480 — 0.985 P09480 →
P02717 — 0.985 P02717 →
Q07263 — 0.985 Q07263 →
P04755 — 0.984 P04755 →