Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | DAGLA | Q9Y4D2 | 4/20 | 0.36 |
| ▸ | CNR1 | P21554 | 3/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | PRKCA | P17252 | 2/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | PRKCG | P05129 | 1/20 | 0.34 |
| ▸ | PRKCB | P05771 | 1/20 | 0.34 |
| ▸ | PRKCH | P24723 | 1/20 | 0.34 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.34 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.34 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.34 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13310153 | 1.00 | TSHR (0.39) | TSHRDAGLACNR1CNR2SIRT2 | |
| SCHEMBL10083943 | 1.00 | TSHR (0.39) | TSHRDAGLACNR1CNR2SIRT2 | |
| SCHEMBL26754374 | 0.83 | DAGLA (0.36) | TSHRDAGLACNR1CNR2MGLL | |
| SCHEMBL26754371 | 0.76 | CYP3A4 (0.37) | TSHRDAGLACNR1CNR2MGLL | |
| SCHEMBL10595512 | 0.67 | TSHR (0.43) | TSHRMAPTHSD17B10GAAALDH1A1 | |
| SCHEMBL19714328 | 0.65 | TSHR (0.58) | TSHRSIRT2MAPTHSD17B10ALDH1A1 | |
| SCHEMBL10848706 | 0.64 | TSHR (0.40) | TSHRSIRT2BRD4MAPTHSD17B10 | |
| SCHEMBL10038782 | 0.63 | TSHR (0.39) | TSHRSIRT2MAPTHSD17B10GAA | |
| SCHEMBL14104694 | 0.63 | TSHR (0.39) | TSHRSIRT2MAPTHSD17B10GAA | |
| SCHEMBL11687845 | 0.63 | HSD17B10 (0.52) | TSHRBRD4MAPTHSD17B10GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8124794-B2 | Method for the asymmetric synthesis of beta-lactone compounds | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2012-02-28 | — | — | US | disclosed |
| US-20100173982-A1 | NOVEL METHOD FOR THE ASYMMETRIC SYNTHESIS OF BETA-LACTONE COMPOUNDS | THE BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173982-A1 | NOVEL METHOD FOR THE ASYMMETRIC SYNTHESIS OF BETA-LACTONE COMPOUNDS | FASN, COASY, FADS1 | TSHR 4308/4885DAGLA 228/4885CNR1 1240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.