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Sugi Predict / Targets / FADS1

FADS1

Acyl-CoA (8-3)-desaturase · O60427 · FADS1 on Sugi Atlas →

14,499 patent compounds predicted against FADS1, 8,604 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL801673 SCHEMBL801673 0.55 8/20
SCHEMBL802253 SCHEMBL802253 0.55 8/20
SCHEMBL801419 SCHEMBL801419 0.69 7/20
SCHEMBL801921 SCHEMBL801921 0.54 7/20
SCHEMBL1228963 SCHEMBL1228963 0.49 7/20
SCHEMBL472983 SCHEMBL472983 0.78 6/20
SCHEMBL1268405 SCHEMBL1268405 0.54 6/20
SCHEMBL801665 SCHEMBL801665 0.51 6/20
SCHEMBL1686631 SCHEMBL1686631 0.59 5/20
SCHEMBL801664 SCHEMBL801664 0.52 5/20
SCHEMBL330366 SCHEMBL330366 0.69 4/20
SCHEMBL734843 SCHEMBL734843 0.61 4/20
SCHEMBL574119 SCHEMBL574119 0.58 4/20
SCHEMBL1499498 SCHEMBL1499498 0.58 4/20
SCHEMBL1351311 SCHEMBL1351311 0.57 4/20
SCHEMBL627286 SCHEMBL627286 0.57 4/20
SCHEMBL1230073 SCHEMBL1230073 0.56 4/20
SCHEMBL415567 SCHEMBL415567 0.55 4/20
SCHEMBL802142 SCHEMBL802142 0.55 4/20
SCHEMBL786203 SCHEMBL786203 0.54 4/20

Clinical trials — most relevant to FADS1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Role of Pioglitazone in the Treatment of Non-alcoholic Steatohepatitis (NASH) PHASE4COMPLETED
Effects of Fenofibrate Therapy in Diabetic Nephropathy PHASE3UNKNOWN
Fish Oil Supplementation, Nutrigenomics and Colorectal Cancer Prevention PHASE2COMPLETED
The Effects of Coenzyme A Combined With Abiraterone on Patients With CRPC PHASE1/PHASE2UNKNOWN
Toxicity and Efficacy Evaluation of Topical Minoxidil in Acne Vulgaris PHASE1/PHASE2UNKNOWN
Polyunsaturated Fatty Acids (PUFA) in Diabetic Fatty Liver PHASE2COMPLETED
Metabolic Cofactor Supplementation in Obese Patients With Non-Alcoholic Fatty Liver Disease PHASE2COMPLETED
Atorvastatin, L-Carnitine and Non-Alcoholic Steatohepatitis PHASE2UNKNOWN
A Pilot Study of High-Dose Omega-3 (Soloways ™) Polyunsaturated Fatty Acids in Patients with Dyslipidemia Carrying FADS1/FADS2 Variants nanCOMPLETED
Canola Oil Multicentre Intervention Trial nanCOMPLETED
Screening of Healthy Adults for Genetic Variations That Control Fatty Acid Processing nanCOMPLETED
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish) nanUNKNOWN
Fatty Acid Desaturase Gene Locus Interactions With Diet (FADSDIET2) nanCOMPLETED
Effect of Consuming n-3 Polyunsaturated Fatty Acids Rich Foods on Triglyceride Concentration and Lipoprotein Composition nanRECRUITING
Role of Polyunsaturated Fatty Acids (PUFA)-Gene Interactions in Heath Disparities nanCOMPLETED
Fatty Acid Oxidation Defects and Insulin Sensitivity nanCOMPLETED
Lifestyle Intervention in Preparation for Pregnancy (LIPP) nanCOMPLETED
Action of Essential Fatty Acids on the Expression of Antioxidant Genes and Athletic Performance nanCOMPLETED
Familial Partial Lipodystrophy Study nanCOMPLETED
Fish Oil and Nonalcoholic Fatty Liver Disease (NAFLD) Study nanCOMPLETED
Acute Fatty Acid Intervention Study (AFAST) nanCOMPLETED
Effect of Omega-3 Fatty Acids Supplementation on Hypertriglyceridemia in Pediatric Patients With Obesity. nanCOMPLETED
Dietary Fatty Acids, PPAR Activated Genes, and CHD nanCOMPLETED
A Comparison of the Metabolic Effects of Zinc-Amino Acid (ZnAA) Versus Zinc Gluconate nanUNKNOWN
Serum FFA Desaturase Activity Index in Patients on High Dose Corticosteroids nanUNKNOWN
Genes, Omega-3 Fatty Acids and Cardiovascular Disease Risk Factors nanACTIVE_NOT_RECRUITING
The Safety and Efficacy Study of RiaGev in Healthy Adults nanUNKNOWN
Omega-3 vs Very Low Calorie Diet for Liver Size Reduction nanUNKNOWN
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Genetic and Environmental Determinants of Triglycerides (GOLDN) nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a FADS1 binder may also engage these)

ProteinNameSimilarity
A4UVI1 — 1.000 A4UVI1 →
Q920R3 — 1.000 Q920R3 →
Q920L1 — 1.000 Q920L1 →
Q5REA7 — 1.000 Q5REA7 →
B2KKL4 — 0.999 B2KKL4 →
D8X2C5 — 0.999 D8X2C5 →
A4IFP3 — 0.998 A4IFP3 →
FADS2 Acyl-CoA 6-desaturase 0.998 landscape →
B8R1K0 — 0.997 B8R1K0 →
A4FV48 — 0.997 A4FV48 →
Q4R749 — 0.995 Q4R749 →
Q9DEX7 — 0.995 Q9DEX7 →
Q9Z0R9 — 0.994 Q9Z0R9 →
A0A0C5PRW9 — 0.993 A0A0C5PRW9 →
Q8K1P9 — 0.992 Q8K1P9 →
Q9Z122 — 0.992 Q9Z122 →
Q6DDK2 — 0.992 Q6DDK2 →
Q9JJE7 — 0.991 Q9JJE7 →
Q9Y5Q0 — 0.990 Q9Y5Q0 →
Q23221 — 0.983 Q23221 →
Q3EBF7 — 0.982 Q3EBF7 →
Q43469 — 0.980 Q43469 →
G5EG11 — 0.979 G5EG11 →
P46312 — 0.977 P46312 →
Q0VAX3 — 0.976 Q0VAX3 →
P48618 — 0.976 P48618 →
Q9ZRP7 — 0.975 Q9ZRP7 →
A4KDP0 — 0.975 A4KDP0 →
P48623 — 0.974 P48623 →
P32291 — 0.974 P32291 →