Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | THRA | P10827 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13380209 | 0.96 | HTT (0.53) | HTTPOLBL3MBTL1NPC1CYP3A4 | |
| SCHEMBL16083524 | 0.96 | HTT (0.53) | HTTPOLBL3MBTL1NPC1CYP3A4 | |
| SCHEMBL20631194 | 0.89 | HTT (0.51) | HTTPOLBNPC1CYP3A4LMNA | |
| SCHEMBL3994052 | 0.88 | POLB (0.50) | HTTPOLBL3MBTL1NPC1CYP3A4 | |
| SCHEMBL13394026 | 0.88 | LMNA (0.50) | HTTPOLBL3MBTL1NPC1CYP3A4 | |
| SCHEMBL26651124 | 0.88 | HTT (0.53) | HTTPOLBL3MBTL1NPC1CYP3A4 | |
| SCHEMBL4770398 | 0.87 | POLB (0.54) | HTTPOLBL3MBTL1NPC1CYP3A4 | |
| SCHEMBL6098829 | 0.87 | POLB (0.54) | HTTPOLBL3MBTL1NPC1CYP3A4 | |
| SCHEMBL7521404 | 0.87 | HTT (0.56) | HTTPOLBL3MBTL1NPC1CYP3A4 | |
| SCHEMBL23124356 | 0.86 | HTT (0.48) | HTTPOLBL3MBTL1NPC1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012044577-A1 | DUAL INHIBITORS OF MET AND VEGF FOR THE TREATMENT OF CASTRATION RESISTANT PROSTATE CANCER AND OSTEOBLASTIC BONE METASTASES | EXELIXIS, INC. (US) | 2012-04-05 | — | — | WO | disclosed |