Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 20/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL438942 | 1.00 | CALCRL (0.74) | CALCRLCYP3A4 | |
| SCHEMBL15701570 | 1.00 | CALCRL (0.74) | CALCRLCYP3A4 | |
| SCHEMBL438938 | 0.94 | CALCRL (0.75) | CALCRLCYP3A4 | |
| SCHEMBL10076771 | 0.94 | CALCRL (0.75) | CALCRLCYP3A4 | |
| SCHEMBL440261 | 0.89 | CALCRL (0.60) | CALCRLCYP3A4 | |
| SCHEMBL439055 | 0.89 | CALCRL (0.60) | CALCRLCYP3A4 | |
| SCHEMBL440882 | 0.87 | CALCRL (0.66) | CALCRLCYP3A4 | |
| SCHEMBL437043 | 0.87 | CALCRL (0.66) | CALCRLCYP3A4 | |
| SCHEMBL15701571 | 0.87 | CALCRL (0.66) | CALCRLCYP3A4 | |
| SCHEMBL3889333 | 0.85 | CALCRL (1.00) | CALCRLCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140128375-A1 | BENZAZEPINE COMPOUNDS AS CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. | 2014-05-08 | — | — | US | disclosed |
| US-20120065190-A1 | BENZAZEPINE COMPOUNDS AS CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140128375-A1 | BENZAZEPINE COMPOUNDS AS CGRP RECEPTOR ANTAGONISTS | BDKRB1, BDKRB2, CALCRL | CALCRL 3/4885CYP3A4 1522/4885 |
| US-20120065190-A1 | BENZAZEPINE COMPOUNDS AS CGRP RECEPTOR ANTAGONISTS | BDKRB1, BDKRB2, CALCRL | CALCRL 3/4885CYP3A4 1522/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.