BDKRB2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Fr-173657 (SCHEMBL1559539)	1.00	20/20
SCHEMBL1562938	1.00	20/20
SCHEMBL1563101	1.00	20/20
SCHEMBL1563164	1.00	20/20
SCHEMBL1563181	1.00	20/20
SCHEMBL1563888	1.00	20/20
SCHEMBL1563340	0.88	20/20
SCHEMBL1563801	0.87	20/20
SCHEMBL1563320	0.86	20/20
SCHEMBL1563859	0.86	20/20
SCHEMBL1563785	0.85	20/20
SCHEMBL1563942	0.85	20/20
SCHEMBL1563837	0.82	20/20
SCHEMBL1563721	0.81	20/20
SCHEMBL1563939	0.81	20/20
SCHEMBL1563856	0.81	20/20
SCHEMBL1563132	0.79	20/20
SCHEMBL1563195	0.78	20/20
SCHEMBL1563768	0.78	20/20
SCHEMBL1563086	0.77	20/20

Clinical trials — most relevant to BDKRB2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Kallikrein-kinin (KKS) and Renin-angiotensin-aldosterone System (RAAS) in Primary Aldosteronism	PHASE4	COMPLETED
Clonidine vs. Dexmedetomidine in Agitated Delirium in Intensive Care Patients	PHASE4	UNKNOWN
Reversal of Acute β-Blocker Induced Bronchoconstriction	PHASE4	COMPLETED
Bradykinin Receptor Antagonism During Cardiopulmonary Bypass	PHASE2/PHASE3	COMPLETED
Ramatroban/Montelukast Versus Montelukast/Placebo on the Early Allergic Reaction in Asthma Sensitive to House Dust Mite	PHASE2/PHASE3	WITHDRAWN
The Role of Angiotensin Type I Receptor in the Regulation of Human Peripheral Vascular Function	PHASE3	COMPLETED
The Role of Angiotensin Type I Receptor in the Regulation of Human Coronary Vascular Function	PHASE3	COMPLETED
Efficacy and Safety Study of Azilsartan Medoxomil Compared to Ramipril for Treating Essential Hypertension	PHASE3	COMPLETED
Bradykinin Receptors and Pain	PHASE2	COMPLETED
A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin	PHASE2	UNKNOWN
Impact of Exercise Training on Endothelial Function in CAD	PHASE2	UNKNOWN
Vasoreactivity in Carriers of Genetic Polymorphisms	PHASE1	UNKNOWN
Effects of Miconazole on Blood Flow	PHASE1	COMPLETED
Involvement of Monocytic B1 and B2 Receptors in Inflammation and Chronic Vascular Disease in Patients With Hereditary Bradykinetic Angioedema	nan	COMPLETED
Forced Oscillometry in Infants With Bronchopulmonary Dysplasia	nan	RECRUITING
Study of the Interaction Between the Cells Lining Blood Vessels and Angiotensin-Converting Enzyme	nan	COMPLETED
Evaluating Long Acting Beta Agonists Used to Treat Asthma Among Those With Either Arg/Arg or Gly/Gly Genotypes	nan	COMPLETED
Long Term Effects of Enalapril and Losartan on Genetic Heart Disease	nan	COMPLETED
Role of B2 Adrenergic Receptors in Labor Pain	nan	COMPLETED
B2 Adrenergic Receptor Gene Polymorphism in Bronchial Asthma	nan	UNKNOWN
Searching for Novel Therapeutic Approaches in Migraine Patients Resistant to Treatments	nan	RECRUITING
Selective Activation of the Adrenomedullin Receptors in Migraine	nan	NOT_YET_RECRUITING
Autonomic Nervous System Profile in Hereditary Angioedema	nan	COMPLETED
Efficacy and Safety of Angiotensin II Use in Coronavirus Disease(COVID)-19 Patients With Acute Respiratory Distress Syndrome	nan	UNKNOWN
Changes After Angiotensin Converting Enzyme (ACE) Inhibitor Replacement by Angiotensin II Receptor Type I (AT1) Blocker	nan	UNKNOWN
Racial Variation in ACE--Genetic and Physiologic Bases	nan	COMPLETED
Acute Airway Vascular Smooth Muscle Effects of Inhaled Budesonide	nan	COMPLETED
Genetic Influences of Albuterol Response In Children With Bronchiolitis	nan	COMPLETED
HYPGENE-Genetics Fitness Obesity & Risk of Hypertension	nan	COMPLETED
The Effect of Ischaemic-Reperfusion in Man - A Bradykinin Dependent Pathway	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a BDKRB2 binder may also engage these)

Protein	Name	Similarity
P25023	—	1.000	P25023 →
Q9GLX8	—	1.000	Q9GLX8 →
P32299	—	1.000	P32299 →
O70526	—	1.000	O70526 →
Q28642	—	0.997	Q28642 →
B3G515	—	0.981	B3G515 →
Q9Z282	—	0.979	Q9Z282 →
P31392	—	0.979	P31392 →
P79960	—	0.978	P79960 →
Q4VA82	—	0.978	Q4VA82 →
B0F9W3	—	0.977	B0F9W3 →
P46094	—	0.976	P46094 →
GPR132	Probable G-protein coupled receptor 132	0.976	landscape →
E7FEL0	—	0.976	E7FEL0 →
HCAR2	Hydroxycarboxylic acid receptor 2	0.976	landscape →
Q2TAD5	—	0.975	Q2TAD5 →
P43142	—	0.974	P43142 →
P79785	—	0.974	P79785 →
Q28003	—	0.974	Q28003 →
Q9WV08	—	0.974	Q9WV08 →
Q8BUD0	—	0.974	Q8BUD0 →
P56484	—	0.974	P56484 →
Q9WUT7	—	0.974	Q9WUT7 →
O46685	—	0.973	O46685 →
P97583	—	0.973	P97583 →
Q80Z39	—	0.973	Q80Z39 →
CCR7	C-C chemokine receptor type 7	0.973	landscape →
CXCR2	C-X-C chemokine receptor type 2	0.972	landscape →
CCR4	C-C chemokine receptor type 4	0.972	landscape →
P29754	—	0.972	P29754 →