Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 2/20 | 0.42 |
| ▸ | ACE | P12821 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13613236 | 0.91 | HTRA1 (0.39) | ACEMEN1KMT2AUSP2LMNA | |
| SCHEMBL14350234 | 0.91 | HTRA1 (0.39) | ACEMEN1KMT2AUSP2LMNA | |
| SCHEMBL14376884 | 0.91 | HTRA1 (0.39) | ACEMEN1KMT2AUSP2LMNA | |
| SCHEMBL10076845 | 0.91 | HTRA1 (0.39) | ACEMEN1KMT2AUSP2LMNA | |
| SCHEMBL3050903 | 0.91 | HTRA1 (0.39) | ACEMEN1KMT2AUSP2LMNA | |
| SCHEMBL10076848 | 0.87 | ACE (0.41) | F2ACEMEN1KMT2AUSP2 | |
| SCHEMBL13613239 | 0.87 | ACE (0.41) | F2ACEMEN1KMT2AUSP2 | |
| SCHEMBL3052690 | 0.87 | ACE (0.41) | F2ACEMEN1KMT2AUSP2 | |
| SCHEMBL14350258 | 0.87 | ACE (0.41) | F2ACEMEN1KMT2AUSP2 | |
| SCHEMBL13613245 | 0.78 | CTSB (0.40) | F2ELANECTSLCTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2468744-A2 | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-27 | — | — | EP | disclosed |