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Sugi Predict / Targets / CTSB

CTSB

Cathepsin B · P07858 · CTSB on Sugi Atlas →

229,962 patent compounds predicted against CTSB, 133,530 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Telaprevir Telaprevir (SCHEMBL183996) 1.00 13/20
Telaprevir Telaprevir (SCHEMBL184177) 1.00 13/20
SCHEMBL190803 SCHEMBL190803 0.54 11/20
SCHEMBL52449 SCHEMBL52449 0.52 8/20
SCHEMBL87370 SCHEMBL87370 0.51 8/20
SCHEMBL51465 SCHEMBL51465 0.49 7/20
SCHEMBL192070 SCHEMBL192070 0.47 7/20
SCHEMBL191969 SCHEMBL191969 0.45 7/20
SCHEMBL25562 SCHEMBL25562 0.36 7/20
Mg-132 Mg-132 (SCHEMBL160925) 0.72 6/20
SCHEMBL62133 SCHEMBL62133 0.49 6/20
SCHEMBL52043 SCHEMBL52043 0.48 6/20
SCHEMBL142265 SCHEMBL142265 0.48 6/20
SCHEMBL24199 SCHEMBL24199 0.35 6/20
SCHEMBL7094 SCHEMBL7094 0.56 5/20
SCHEMBL109568 SCHEMBL109568 0.55 5/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL70796) 0.48 5/20
SCHEMBL87346 SCHEMBL87346 0.47 5/20
SCHEMBL143289 SCHEMBL143289 0.46 5/20
SCHEMBL142589 SCHEMBL142589 0.46 5/20

Clinical trials — most relevant to CTSB by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Imatinib in KIT-negative Systemic Mastocytosis PHASE4COMPLETED
Strategies to Reduce Organic Muscle Atrophy in the Intensive Care Unit PHASE2/PHASE3WITHDRAWN
Efficacy and Safety of Favipiravir and Ribavirin Formulation for Treatment of COVID-19 PHASE2/PHASE3UNKNOWN
STOP-COVID19: Superiority Trial Of Protease Inhibition in COVID-19 PHASE3COMPLETED
Zoledronic Acid or Methylprednisolone for Active Charcot's Neuroarthropathy of Foot in Patients With Diabetes Mellitus PHASE2/PHASE3COMPLETED
Single Dosing of Zoledronic Acid in Cancer Therapy Induced Bone Loss (CTIBL) PHASE3COMPLETED
Comparative Clinical Study to Evaluate the Possible Efficacy and Safety of Oral N-Acetyl Cysteine Versus Rectal Diclofenac in the Prevention of Post Endoscopic Retrograde Cholangiopancreatography Pancreatitis PHASE1/PHASE2COMPLETED
A Phase I Study Of Thymoglobulin In Patients With Relapsed Or Refractory Multiple Myeloma PHASE1COMPLETED
The Study of Quadruple Therapy Quercetin, Zinc, Metformin, and EGCG as Adjuvant Therapy for Early, Metastatic Breast Cancer and Triple-negative Breast Cancer, a Novel Mechanism EARLY_PHASE1UNKNOWN
Respiratory Cathepsins, Proteases Inhibitors and Glycosaminoglycans (GAG) in Mucopolysaccharidosis nanCOMPLETED
Turkish Adaptation of the CTS-6 Evaluation Tool: A Validation and Reliability Study nanNOT_YET_RECRUITING
Diagnostic Value of Serum Cathepsin S and Chromogranin A in DKD nanNOT_YET_RECRUITING
Hematological Markers in Idiopathic Carpal Tunnel Syndrome nanCOMPLETED
Multimodal Approach of Electrotherapy Versus Nerve Flossing Technique in Patient With Carpal Tunnel Syndrome nanUNKNOWN
Synovial Fluid Bank From Arthritic Patients nanRECRUITING
Rab 32 Gene Polymorphisms as a Prognostic Factor in Leprosy Patients nanRECRUITING
Chemokine Mechanisms in Chronic Pelvic Pain nanCOMPLETED
Correlation Between Serum Markers of Unstable Plaque and Virtual Histology of Unstable Plaque Visualized by IVUS nanCOMPLETED
Salivary Biomarkers for Sjögren's Syndrome Detection nanCOMPLETED
Surfactant Derived Protocol in Heart Failure nanCOMPLETED
Fasting, Exercise, and Diet to Activate Autophagy in Depression nanNOT_YET_RECRUITING
Predicting Pancreatic Necrosis Using mitDNA nanUNKNOWN
The Role of Vitamin K2 in Preventing Glucocorticoid-Induced Bone Loss in Children With Nephrotic Syndrome nanRECRUITING
Influence of Statins in Artery Aneurysms nanUNKNOWN
Comparison of Clinical Efficacy of Submucosal Dexamethasone and Oral Trypsin-chymotrypsin for Reduction of Postoperative Sequelae After Lower Third Molar Surgery nanRECRUITING
Role of A Disintegrin and Metalloproteinase (ADAM) in Epithelial Dysfunction nanCOMPLETED
Proteases in Patients With Prostate Cancer That Has Spread to the Bone nanCOMPLETED
Effect of Exercise on Ultrasound SWV in CTS Patients nanCOMPLETED
Hydrodissection Between Normal Saline and a Combination of Triamcinolone Acetonide, Normal Saline, and Lidocaine in CTS nanCOMPLETED
Bace1as Role in Heart Failure (BACE1AS-HF) nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a CTSB binder may also engage these)

ProteinNameSimilarity
Q5R6D1 — 1.000 Q5R6D1 →
Q4R5M2 — 1.000 Q4R5M2 →
P83205 — 1.000 P83205 →
A1E295 — 1.000 A1E295 →
P07688 — 1.000 P07688 →
P43233 — 0.995 P43233 →
P00787 — 0.995 P00787 →
Q9UJW2 — 0.991 Q9UJW2 →
P10605 — 0.991 P10605 →
P43509 — 0.988 P43509 →
CTSS Cathepsin S 0.988 landscape →
P25802 — 0.988 P25802 →
P05689 — 0.987 P05689 →
CTSZ Cathepsin Z 0.986 landscape →
P90850 — 0.986 P90850 →
P25792 — 0.985 P25792 →
P43157 — 0.985 P43157 →
O70370 — 0.985 O70370 →
P25326 — 0.984 P25326 →
G5EGP8 — 0.984 G5EGP8 →
P25793 — 0.983 P25793 →
P19092 — 0.983 P19092 →
P06797 — 0.982 P06797 →
Q9WUU7 — 0.982 Q9WUU7 →
P43508 — 0.982 P43508 →
Q9R1T3 — 0.982 Q9R1T3 →
Q94K85 — 0.981 Q94K85 →
Q3SZI1 — 0.981 Q3SZI1 →
Q8VYS0 — 0.981 Q8VYS0 →
P25773 — 0.980 P25773 →