Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 18/20 | 1.00 |
| ▸ | TP53 | P04637 | 9/20 | 1.00 |
| ▸ | GAA | P10253 | 15/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.68 |
| ▸ | HTT | P42858 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19568911 | 0.82 | MAPT (1.00) | MAPTTP53GAASMN1; SMN2KDM4E | |
| SCHEMBL12360676 | 0.81 | MAPT (1.00) | MAPTTP53GAASMN1; SMN2KDM4E | |
| SCHEMBL19568944 | 0.81 | MAPT (0.69) | MAPTTP53GAASMN1; SMN2KDM4E | |
| SCHEMBL17131808 | 0.78 | MAPT (0.89) | MAPTTP53GAASMN1; SMN2KDM4E | |
| SCHEMBL10077268 | 0.76 | MAPT (1.00) | MAPTTP53GAASMN1; SMN2KDM4E | |
| SCHEMBL10077405 | 0.75 | MAPT (1.00) | MAPTTP53GAASMN1; SMN2KDM4E | |
| SCHEMBL2249830 | 0.73 | MAPT (0.70) | MAPTTP53GAASMN1; SMN2KDM4E | |
| SCHEMBL17131819 | 0.72 | MAPT (1.00) | MAPTTP53GAASMN1; SMN2TDP1 | |
| SCHEMBL19569163 | 0.72 | MAPT (0.83) | MAPTTP53GAASMN1; SMN2KDM4E | |
| SCHEMBL10077266 | 0.71 | MAPT (1.00) | MAPTTP53GAASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012016133-A2 | ROS1 KINASE INHIBITORS FOR THE TREATMENT OF GLIOBLASTOMA AND OTHER P53-DEFICIENT CANCERS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-02-02 | — | — | WO | disclosed |