Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 17/20 | 0.69 |
| ▸ | GAA | P10253 | 14/20 | 0.69 |
| ▸ | TP53 | P04637 | 8/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | HTT | P42858 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10077260 | 0.81 | MAPT (1.00) | MAPTGAATP53SMN1; SMN2HTT | |
| SCHEMBL17131808 | 0.80 | MAPT (0.89) | MAPTGAATP53SMN1; SMN2HTT | |
| SCHEMBL12360676 | 0.79 | MAPT (1.00) | MAPTGAATP53SMN1; SMN2HTT | |
| SCHEMBL2249830 | 0.74 | MAPT (0.70) | MAPTGAATP53SMN1; SMN2HTT | |
| SCHEMBL17131819 | 0.74 | MAPT (1.00) | MAPTGAATP53SMN1; SMN2HTT | |
| SCHEMBL10077405 | 0.73 | MAPT (1.00) | MAPTGAATP53SMN1; SMN2HTT | |
| SCHEMBL2252270 | 0.72 | MAPT (0.55) | MAPTGAATP53SMN1; SMN2HTT | |
| SCHEMBL2254064 | 0.72 | MAPT (0.72) | MAPTGAATP53SMN1; SMN2HTT | |
| SCHEMBL2252362 | 0.71 | MAPT (0.65) | MAPTGAATP53SMN1; SMN2HTT | |
| SCHEMBL2252221 | 0.71 | MAPT (0.69) | MAPTGAATP53SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11065251-B2 | PAK1 inhibitors and uses thereof | ALBERT EINSTEIN COLLEGE OF MEDICINE (US) | 2021-07-20 | — | — | US | disclosed |
| US-11065251-B2 | PAK1 inhibitors and uses thereof | ALBERT EINSTEIN COLLEGE OF MEDICINE (US) | 2021-07-20 | — | — | US | disclosed |
| US-20200323855-A1 | PAK1 INHIBITORS AND USES THEREOF | ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. (US) | 2020-10-15 | — | — | US | disclosed |
| US-20200323855-A1 | PAK1 INHIBITORS AND USES THEREOF | ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. (US) | 2020-10-15 | — | — | US | disclosed |
| WO-2017192228-A1 | PAK1 INHIBITORS AND USES THEREOF | ALBERT EINSTEIN COLLEGE OF MEDICINE, INC. (US) | 2017-11-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11065251-B2 | PAK1 inhibitors and uses thereof | PAK1, CDC42, CDC42BPG | MAPT 3472/4885GAA 3778/4885TP53 192/4885 |
| US-20200323855-A1 | PAK1 INHIBITORS AND USES THEREOF | PAK1, CDC42, CDC42BPG | MAPT 3472/4885GAA 3778/4885TP53 192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.