Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 17/20 | 1.00 |
| ▸ | GAA | P10253 | 17/20 | 1.00 |
| ▸ | TP53 | P04637 | 6/20 | 1.00 |
| ▸ | THRB | P10828 | 1/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.68 |
| ▸ | POLB | P06746 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | USP2 | O75604 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10077270 | 0.85 | GAA (1.00) | MAPTGAATP53THRBSMN1; SMN2 | |
| SCHEMBL10077274 | 0.81 | GAA (1.00) | MAPTGAATP53THRBSMN1; SMN2 | |
| SCHEMBL31344107 | 0.81 | MAPT (1.00) | MAPTGAATP53THRBSMN1; SMN2 | |
| SCHEMBL10077294 | 0.81 | MAPT (1.00) | MAPTGAATP53THRBSMN1; SMN2 | |
| SCHEMBL10077268 | 0.79 | MAPT (1.00) | MAPTGAATP53THRBSMN1; SMN2 | |
| SCHEMBL31344185 | 0.79 | MAPT (0.79) | MAPTGAATP53THRBSMN1; SMN2 | |
| SCHEMBL10077283 | 0.79 | GAA (1.00) | MAPTGAATP53THRBSMN1; SMN2 | |
| SCHEMBL19569163 | 0.77 | MAPT (0.83) | MAPTGAATP53THRBSMN1; SMN2 | |
| SCHEMBL14016030 | 0.77 | MAPT (0.75) | MAPTGAATP53THRBSMN1; SMN2 | |
| SCHEMBL2255349 | 0.77 | MAPT (0.66) | MAPTGAATP53THRBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012016133-A2 | ROS1 KINASE INHIBITORS FOR THE TREATMENT OF GLIOBLASTOMA AND OTHER P53-DEFICIENT CANCERS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-02-02 | — | — | WO | disclosed |