Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLPP | Q16740 | 8/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4392728 | 0.85 | CLPP (0.38) | CLPPALDH1A1LMNASMN1; SMN2KDM4E | |
| SCHEMBL4392377 | 0.76 | CLPP (0.36) | CLPPALDH1A1LMNASMN1; SMN2KDM4E | |
| SCHEMBL4393723 | 0.73 | CYP2C9 (0.36) | ALDH1A1KDM4E | |
| SCHEMBL4401303 | 0.73 | CYP2C9 (0.36) | TP53 | |
| SCHEMBL4398133 | 0.73 | CYP2C9 (0.36) | — | |
| SCHEMBL4397400 | 0.73 | MAPK8 (0.36) | PLA2G7 | |
| SCHEMBL4399670 | 0.70 | SCD (0.43) | CLPPALDH1A1LMNASMN1; SMN2KDM4E | |
| SCHEMBL4397223 | 0.70 | CYP2C9 (0.37) | — | |
| SCHEMBL4403363 | 0.69 | F2 (0.34) | CLPPLMNATSHR | |
| SCHEMBL4393694 | 0.69 | FNTA (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919921-B1 | BICYCLIC HETEROCYCLES AS HIV INTEGRASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2012-06-27 | — | — | EP | disclosed |