Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.38 |
| ▸ | TUBB | P07437 | 3/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10077959 | 0.86 | HPGD (0.41) | NPC1RAB9ARXFP1ALDH1A1HPGD | |
| SCHEMBL832595 | 0.82 | ALDH1A1 (0.48) | NPC1RAB9AALDH1A1HPGDKDM4E | |
| SCHEMBL829516 | 0.81 | ALDH1A1 (0.55) | NPC1RAB9ARXFP1ALDH1A1HPGD | |
| SCHEMBL828877 | 0.80 | ALDH1A1 (0.48) | NPC1RAB9ARXFP1ALDH1A1HPGD | |
| SCHEMBL829884 | 0.80 | GAA (0.49) | NPC1RAB9ARXFP1ALDH1A1HPGD | |
| SCHEMBL10077948 | 0.79 | HPGD (0.41) | NPC1RAB9ARXFP1ALDH1A1HPGD | |
| SCHEMBL383862 | 0.79 | ALDH1A1 (0.64) | NPC1RAB9AALDH1A1HPGDKDM4E | |
| SCHEMBL388750 | 0.79 | MEN1 (0.48) | NPC1RAB9ARXFP1ALDH1A1HPGD | |
| SCHEMBL12890683 | 0.79 | ALDH1A1 (0.47) | NPC1RAB9ARXFP1ALDH1A1HPGD | |
| SCHEMBL862239 | 0.77 | ALDH1A1 (0.52) | NPC1RAB9ARXFP1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081922-B1 | 5,6-Ring annulated indole derivatives and use thereof | SCHERING CORP (US) | 2012-02-01 | — | — | EP | disclosed |
| WO-2008136815-A2 | 5, 6-RING ANNULATED INDOLE DERIVATIVES AND USE THEREOF | SCHERING CORPORATION (US) | 2008-11-13 | — | — | WO | disclosed |