Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP8B1 | Q9UNU6 | 1/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.33 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10078619 | 1.00 | CYP8B1 (0.42) | CYP8B1PIM2PIM3PIK3CACYP2C19 | |
| SCHEMBL1224184 | 0.87 | CYP8B1 (0.41) | CYP8B1PIK3CAACVR1KCNH2PIK3CD | |
| SCHEMBL1224187 | 0.87 | CYP8B1 (0.41) | CYP8B1PIK3CAACVR1KCNH2PIK3CD | |
| SCHEMBL1224035 | 0.86 | CYP2C19 (0.43) | CYP8B1PIK3CACYP2C19ACVR1KCNH2 | |
| SCHEMBL1222910 | 0.86 | CYP8B1 (0.40) | CYP8B1PIM2PIM3PIK3CACYP2C19 | |
| SCHEMBL3671689 | 0.86 | CYP8B1 (0.40) | CYP8B1PIM2PIM3PIK3CACYP2C19 | |
| SCHEMBL3671685 | 0.86 | CYP8B1 (0.40) | CYP8B1PIM2PIM3PIK3CACYP2C19 | |
| SCHEMBL1222911 | 0.86 | CYP8B1 (0.40) | CYP8B1PIM2PIM3PIK3CACYP2C19 | |
| SCHEMBL16986064 | 0.84 | CYP8B1 (0.47) | CYP8B1PIM2PIM3PIK3CACYP2C19 | |
| SCHEMBL16986057 | 0.84 | CYP8B1 (0.41) | CYP8B1PIK3CACYP2C19ACVR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2915813-A1 | Oxazolidinone antibiotics | Actelion Pharmaceuticals Ltd. (CH) | 2015-09-09 | — | — | EP | disclosed |
| EP-2905283-A1 | Oxazolidinone antibiotics | Actelion Pharmaceuticals Ltd. (CH) | 2015-08-12 | — | — | EP | disclosed |
| US-8217029-B2 | Oxazolidinone antibiotics | ACTELION PHARMACEUTICALS LTD (CH) | 2012-07-10 | — | — | US | disclosed |