Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP8B1 | Q9UNU6 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1222910 | 1.00 | CYP8B1 (0.40) | CYP8B1CYP2C19PIK3CAACVR1KCNH2 | |
| SCHEMBL1222911 | 1.00 | CYP8B1 (0.40) | CYP8B1CYP2C19PIK3CAACVR1KCNH2 | |
| SCHEMBL3671685 | 1.00 | CYP8B1 (0.40) | CYP8B1CYP2C19PIK3CAACVR1KCNH2 | |
| SCHEMBL1224035 | 0.86 | CYP2C19 (0.43) | CYP8B1CYP2C19PIK3CAACVR1KCNH2 | |
| SCHEMBL10078618 | 0.86 | CYP8B1 (0.42) | CYP8B1CYP2C19PIK3CAACVR1KCNH2 | |
| SCHEMBL10078619 | 0.86 | CYP8B1 (0.42) | CYP8B1CYP2C19PIK3CAACVR1KCNH2 | |
| SCHEMBL16986057 | 0.84 | CYP8B1 (0.41) | CYP8B1CYP2C19PIK3CAACVR1KCNH2 | |
| SCHEMBL16986064 | 0.82 | CYP8B1 (0.47) | CYP8B1CYP2C19PIK3CAKCNH2PIM3 | |
| SCHEMBL1222886 | 0.81 | CYP8B1 (0.41) | CYP8B1ACVR1KCNH2 | |
| SCHEMBL16986073 | 0.80 | CYP8B1 (0.37) | CYP8B1ACVR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2915813-A1 | Oxazolidinone antibiotics | Actelion Pharmaceuticals Ltd. (CH) | 2015-09-09 | — | — | EP | disclosed |
| EP-2905283-A1 | Oxazolidinone antibiotics | Actelion Pharmaceuticals Ltd. (CH) | 2015-08-12 | — | — | EP | disclosed |
| US-8217029-B2 | Oxazolidinone antibiotics | ACTELION PHARMACEUTICALS LTD (CH) | 2012-07-10 | — | — | US | disclosed |
| EP-2144910-A2 | OXAZOLIDINONE ANTIBIOTICS | Actelion Pharmaceuticals Ltd. (CH) | 2010-01-20 | — | — | EP | disclosed |
| WO-2008126034-A2 | OXAZOLIDINONE ANTIBIOTICS | ACTELION PHARMACEUTICALS LTD (CH) | 2008-10-23 | — | — | WO | disclosed |