⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2573471 | 0.74 | — | — | |
| SCHEMBL8780494 | 0.64 | APP (0.48) | — | |
| SCHEMBL7351303 | 0.60 | — | — | |
| SCHEMBL7537901 | 0.58 | — | — | |
| SCHEMBL426923 | 0.57 | — | — | |
| SCHEMBL690070 | 0.57 | — | — | |
| SCHEMBL15382251 | 0.57 | — | — | |
| SCHEMBL29111914 | 0.56 | — | — | |
| SCHEMBL16861487 | 0.54 | — | — | |
| SCHEMBL1686922 | 0.53 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 113 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180334440-A1 | INHIBITORS OF ARGININE GINGIPAIN | Cortexyme, Inc. (US) | 2018-11-22 | — | — | US | claimed |
| EP-3374352-A1 | INHIBITORS OF ARGININE GINGIPAIN | Cortexyme, Inc. (US) | 2018-09-19 | — | — | EP | claimed |
| WO-2017201322-A1 | TREATMENT OF OSTEOARTHRITIS WITH GINGIPAIN BLOCKING AGENTS | Cortexyme, Inc. (US) | 2017-11-23 | — | — | WO | claimed |
| US-9730940-B2 | Purine inhibitors of human phosphatidylinositol 3-kinase delta | MERCK SHARP & DOHME (US) | 2017-08-15 | — | — | US | claimed |
| WO-2017083433-A1 | INHIBITORS OF ARGININE GINGIPAIN | Cortexyme, Inc. (US) | 2017-05-18 | — | — | WO | claimed |
| US-20160096830-A1 | INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2016-04-07 | — | — | US | claimed |
| US-6908926-B1 | Substituted imidazoles, their preparation and use | NOVO NORDISK A/S (DK) | 2005-06-21 | — | — | US | claimed |
| US-11332464-B2 | Inhibitors of lysine gingipain | Cortexyme, Inc. (US) | 2022-05-17 | — | — | US | disclosed |
| US-10906881-B2 | Inhibitors of arginine gingipain | Cortexyme, Inc. (US) | 2021-02-02 | — | — | US | disclosed |
| US-20210017167-A1 | INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2021-01-21 | — | — | US | disclosed |
| CN-111349053-A | Inhibitors of lysine porphyromonas gingivalis protease | 库特克希米公司 | 2020-06-30 | — | — | CN | disclosed |
| US-10676470-B2 | Inhibitors of lysine gingipain | Cortexyme, Inc. (US) | 2020-06-09 | — | — | US | disclosed |
| CN-107108468-B | Inhibitors of lysine porphyromonas gingivalis protease | 库特克希米公司 | 2020-01-03 | — | — | CN | disclosed |
| US-20080004262-A1 | Tricyclic Benzopyrane Compound as Anti-Arrhythmic Agents | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2008-01-03 | — | — | US | disclosed |
| EP-1756084-A2 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2007-02-28 | — | — | EP | disclosed |
| EP-1732929-A1 | TRICYCLIC BENZOPYRAN COMPOUND AS ANTI-ARRHYTHMIC AGENTS | Nissan Chemical Industries, Ltd. (JP) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005121121-A2 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF METABOLISM AND THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2005-12-22 | — | — | WO | disclosed |
| US-20050250793-A1 | Preventives/remedies for hot flash | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-11-10 | — | — | US | disclosed |
| WO-2005090357-A1 | TRICYCLIC BENZOPYRAN COMPOUND AS ANTI-ARRHYTHMIC AGENTS | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2005-09-29 | — | — | WO | disclosed |
| EP-1495768-A1 | PREVENTIVES/REMEDIES FOR HOTFLASH | Takeda Pharmaceutical Company Limited (JP) | 2005-01-12 | — | — | EP | disclosed |