Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.38 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.38 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1097227 | 0.83 | ANO1 (0.40) | ANO1GRIN1GRIN2BALDH1A1GRIN2D | |
| SCHEMBL213165 | 0.80 | GRIN2D (0.56) | ADRA2AADRA2BADRA2CGRIN1GRIN2B | |
| SCHEMBL213164 | 0.80 | GRIN2D (0.56) | ADRA2AADRA2BADRA2CGRIN1GRIN2B | |
| SCHEMBL1095535 | 0.79 | HPGD (0.56) | ANO1GRIN1GRIN2BALDH1A1HPGD | |
| SCHEMBL21222709 | 0.79 | HPGD (0.56) | ANO1GRIN1GRIN2BALDH1A1HPGD | |
| SCHEMBL30444481 | 0.79 | HPGD (0.56) | ANO1GRIN1GRIN2BALDH1A1HPGD | |
| SCHEMBL1095537 | 0.79 | HPGD (0.56) | ANO1GRIN1GRIN2BALDH1A1HPGD | |
| SCHEMBL31182399 | 0.79 | PTGES2 (0.44) | ANO1GRIN1GRIN2BALDH1A1GRIN2D | |
| SCHEMBL1046653 | 0.76 | PTGES2 (0.40) | ANO1GRIN1GRIN2BALDH1A1PTGES2 | |
| SCHEMBL6449354 | 0.74 | ADRA2A (0.57) | ADRA2AADRA2BADRA2CGRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11339147-B2 | Lactam compound as FXR receptor agonist | CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD. (CN) | 2022-05-24 | — | — | US | disclosed |
| US-20200190074-A1 | LACTAM COMPOUND AS FXR RECEPTOR AGONIST | MEDSHINE DISCOVERY INC. (CN) | 2020-06-18 | — | — | US | disclosed |
| WO-2012087521-A1 | COMPOSITIONS AND METHODS FOR MODULATING FARNESOID X RECEPTORS | IRM LLC (BM) | 2012-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11339147-B2 | Lactam compound as FXR receptor agonist | NR1H4, GPBAR1, SLC10A1 | ADRA2A 1042/4885ADRA2B 850/4885ADRA2C 986/4885 |
| US-20200190074-A1 | LACTAM COMPOUND AS FXR RECEPTOR AGONIST | NR1H4, GPBAR1, SLC10A1 | ADRA2A 1042/4885ADRA2B 850/4885ADRA2C 986/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.