ADRA2A

Alpha-2A adrenergic receptor · P08913 · ADRA2A on Sugi Atlas →

459,839 patent compounds predicted against ADRA2A, 310,888 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Brimonidine (SCHEMBL24670)	1.00	20/20
Clonidine (SCHEMBL5983)	1.00	14/20
Bisantrene (SCHEMBL4773)	0.97	9/20
Bisantrene (SCHEMBL7472)	1.00	8/20
Prochlorperazine (SCHEMBL18429)	1.00	7/20
Methylpromazine (SCHEMBL18993)	1.00	6/20
Methylpromazine (SCHEMBL18994)	1.00	6/20
Oxymetazoline (SCHEMBL24301)	1.00	6/20
Ergotamine (SCHEMBL1483)	1.00	5/20
Ketotifen (SCHEMBL4436)	1.00	5/20
Promethazine (SCHEMBL4700)	1.00	5/20
Phentolamine (SCHEMBL5653)	1.00	5/20
Amitriptyline (SCHEMBL7824)	1.00	5/20
Chlorpromazine (SCHEMBL8321)	1.00	5/20
Ketotifen (SCHEMBL8809)	1.00	5/20
Ketotifen (SCHEMBL8810)	1.00	5/20
Bromocriptine (SCHEMBL25297)	1.00	5/20
Levomepromazine (SCHEMBL25462)	1.00	5/20
Ergotamine (SCHEMBL8045)	0.93	5/20
Ergotamine (SCHEMBL8046)	0.93	5/20

Clinical trials — most relevant to ADRA2A by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Dexmedetomidine Affect Diabetic Patient's Glucose Metabolism	PHASE4	UNKNOWN
Clonidine vs. Dexmedetomidine in Agitated Delirium in Intensive Care Patients	PHASE4	UNKNOWN
Lidocaine vs. Lidocaine With Dexmedetomidine for Intravenous Regional Anesthesia (IVRA) in Upper Limb Surgery	PHASE4	RECRUITING
Dexmedetomidine Versus Propofol in Vitreoretinal Surgery	PHASE4	COMPLETED
Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences	PHASE4	RECRUITING
The Cardiopulmonary Effect of Inhaled Beta-2-agonists on Adult Patients Born With Ventricular Septum Defects.	PHASE4	COMPLETED
Dexmedetomidine and Outcomes of Cardiac Surgery (DOCS)	PHASE2/PHASE3	COMPLETED
Use of Dexmedetomidine to Improve Pain Control and Recovery After Laparocopic-Assisted Bowel Surgery in Adults	PHASE3	NOT_YET_RECRUITING
Effect of Remimazolam Sedation on Outcomes of Mechanically Ventilated Patients in the ICU	PHASE3	RECRUITING
Decrease Emergence Agitation and Provide Pain Relief for Children Undergoing Tonsillectomy & Adenoidectomy	PHASE3	COMPLETED
Analgesia After Laparoscopic Cholecystectomy	PHASE2	UNKNOWN
Prazosin for Alcohol Dependence and Posttraumatic Stress Disorder	PHASE2	COMPLETED
Efficacy of Dexmedetomidine As an Adjuvant to Bupivacaine in Pericapsular Nerve Group Block in Hip Replacement Surgeries	PHASE2	NOT_YET_RECRUITING
Effect of Dexmedetomidine on Prevention of Postoperative Nausea and Vomiting in Children	PHASE1	COMPLETED
Vasopressin vs. Epinephrine During Neonatal Cardiopulmonary Resuscitation	PHASE1	ACTIVE_NOT_RECRUITING
Can Caudal Dexmedetomidine Provide Effective Analgesia?	nan	NOT_YET_RECRUITING
Genetic Influences of Albuterol Response In Children With Bronchiolitis	nan	COMPLETED
Brain Receptors in Sympathetic Nervous System Regulation	nan	COMPLETED
Influence of Genetic Polymorphisms on Ventricular Structure and Function in Patients With Single Ventricle Anatomy	nan	COMPLETED
The Locus Coeruleus, Norepinephrine and Cognitive Aging	nan	ACTIVE_NOT_RECRUITING
Ultrasound Guided Rectus Sheath Block and Transversus Abdominis Plane Block	nan	COMPLETED
The Effect of Dexmedetomidine on Oxygen During One Lung Ventilation in Pediatric Surgery.	nan	COMPLETED
Evaluating Long Acting Beta Agonists Used to Treat Asthma Among Those With Either Arg/Arg or Gly/Gly Genotypes	nan	COMPLETED
Renal Denervation in Patients With Chronic Heart Failure	nan	WITHDRAWN
Dexmedetomidine for Pain Reduction in CABG	nan	UNKNOWN
Common Noradrenergic Mechanisms in Parkinson´s Disease and L-DOPA Induced Dyskinesia	nan	UNKNOWN
Articaine Plus Dexmedetomidine in Supraclavicular Block	nan	UNKNOWN
Effect of Dexmedetomidine on Lung Protection in Elderly Patients Undergoing Laparoscopic Surgery for Colorectal Cancer	nan	COMPLETED
Add-on Salmeterol Versus Montelukast in Arg/Arg-16 Asthmatics	nan	COMPLETED
Dexmedetomidine as an Intrathecal Adjuvant to Hyperbaric Bupivacaine for Postoperative Analgesia in Patients Undergoing Arthroscopic Anterior Cruciate Ligament Reconstruction Surgeries	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ADRA2A binder may also engage these)

Protein	Name	Similarity
P22909	—	1.000	P22909 →
Q01338	—	1.000	Q01338 →
Q28838	—	1.000	Q28838 →
P18871	—	1.000	P18871 →
Q60474	—	1.000	Q60474 →
O18935	—	0.994	O18935 →
O19054	—	0.994	O19054 →
P97717	—	0.994	P97717 →
P25115	—	0.994	P25115 →
ADRA1B	Alpha-1B adrenergic receptor	0.992	landscape →
Q60475	—	0.991	Q60475 →
ADRA2C	Alpha-2C adrenergic receptor	0.991	landscape →
P30545	—	0.991	P30545 →
O77700	—	0.990	O77700 →
P34971	—	0.990	P34971 →
P19328	—	0.990	P19328 →
Q6XXX9	—	0.989	Q6XXX9 →
ADRA1D	Alpha-1D adrenergic receptor	0.989	landscape →
P22086	—	0.989	P22086 →
Q9N298	—	0.989	Q9N298 →
O77713	—	0.989	O77713 →
O77830	—	0.988	O77830 →
Q6XXY0	—	0.988	Q6XXY0 →
Q60476	—	0.988	Q60476 →
Q01337	—	0.988	Q01337 →
P23944	—	0.988	P23944 →
O19025	—	0.988	O19025 →
P70174	—	0.987	P70174 →
O77723	—	0.987	O77723 →
O19032	—	0.987	O19032 →