Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.30 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL871534 | 0.92 | HPGD (0.31) | HPGDCYP1A2ITGB1ITGA4POLB | |
| SCHEMBL21863652 | 0.92 | HPGD (0.31) | HPGDCYP1A2POLBCYP3A4CYP2C19 | |
| SCHEMBL21863657 | 0.91 | — | — | |
| SCHEMBL10072318 | 0.90 | ORAI1 (0.31) | HPGDCYP1A2 | |
| SCHEMBL870701 | 0.88 | KMT2A (0.35) | — | |
| SCHEMBL10072316 | 0.87 | PDK2 (0.31) | — | |
| SCHEMBL871329 | 0.87 | CA1 (0.31) | ITGB1ITGA4 | |
| SCHEMBL871098 | 0.87 | P2RX7 (0.30) | — | |
| SCHEMBL10072337 | 0.87 | ORAI1 (0.30) | — | |
| SCHEMBL21253143 | 0.87 | MEN1 (0.35) | ITGB1ITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619189-B1 | ISOXAZOLINE OXIMES AS ANTIPARASITIC AGENTS | ZOETIS SERVICES LLC (US) | 2020-04-15 | — | — | EP | disclosed |
| US-8404649-B2 | Isoxazoline oximes as antiparasitic agents | AH USA 42 LLC (US) | 2013-03-26 | — | — | US | disclosed |
| WO-2012038851-A1 | ISOXAZOLINE OXIMES AS ANTIPARASITIC AGENTS | PFIZER INC. (US) | 2012-03-29 | — | — | WO | disclosed |