Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.62 |
| ▸ | FEN1 | P39748 | 12/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ERCC5 | P28715 | 7/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3634507 | 0.86 | EGLN1 (0.67) | EGLN1FEN1ERCC5 | |
| SCHEMBL30041054 | 0.82 | EGLN1 (0.63) | EGLN1FEN1ALDH1A1ERCC5KCNH2 | |
| SCHEMBL2500134 | 0.79 | EGLN1 (0.66) | EGLN1FEN1ERCC5KCNH2 | |
| SCHEMBL2497674 | 0.79 | ALDH1A1 (0.61) | EGLN1FEN1ALDH1A1 | |
| SCHEMBL2493231 | 0.77 | EGLN1 (1.00) | EGLN1KCNH2 | |
| SCHEMBL14034795 | 0.76 | EGLN1 (0.72) | EGLN1FEN1ERCC5KCNH2 | |
| SCHEMBL4492683 | 0.76 | MEN1 (0.66) | EGLN1FEN1ALDH1A1ERCC5KCNH2 | |
| SCHEMBL2496618 | 0.75 | EGLN1 (0.78) | EGLN1KCNH2 | |
| SCHEMBL29079643 | 0.73 | EGLN1 (0.49) | EGLN1FEN1ALDH1A1ERCC5 | |
| SCHEMBL35212365 | 0.72 | ALDH1A1 (0.74) | ALDH1A1EGFRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150251-B9 | THIENOPYRIDINE AND THIAZOLOPYRIDINE DERIVATIVES THAT INHIBIT PROLYL HYDROXYLASE ACTIVITY | AMGEN INC (US) | 2013-02-27 | — | — | EP | disclosed |
| EP-2150251-B1 | THIENOPYRIDINE AND THIAZOLOPYRIDINE DERIVATIVES THAT INHIBIT PROLYL HYDROXYLASE ACTIVITY | AMGEN INC (US) | 2012-06-27 | — | — | EP | disclosed |