Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 1/20 | 0.53 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.53 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.53 |
| ▸ | S100A4 | P26447 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | CTSV | O60911 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | C1R | P00736 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10081740 | 0.81 | S100A4 (0.53) | S100A4PARP1TDP1TSHRMAPT | |
| SCHEMBL29903883 | 0.80 | MEN1 (0.65) | S100A4PARP1TDP1TSHRMAPT | |
| SCHEMBL8623371 | 0.80 | MEN1 (0.65) | S100A4PARP1TDP1TSHRMAPT | |
| SCHEMBL29450699 | 0.80 | MEN1 (0.65) | S100A4PARP1TDP1TSHRMAPT | |
| SCHEMBL311661 | 0.79 | S100A4 (0.68) | S100A4PARP1TDP1TSHRMAPT | |
| SCHEMBL5575186 | 0.79 | HPRT1 (0.64) | S100A4PARP1TDP1TSHRMAPT | |
| SCHEMBL27054914 | 0.77 | TSHR (0.50) | TDP1TSHRMAPTKMT2AMEN1 | |
| SCHEMBL29715190 | 0.77 | TSHR (0.50) | TDP1TSHRMAPTKMT2AMEN1 | |
| SCHEMBL1527627 | 0.77 | TSHR (0.62) | S100A4TDP1TSHRMAPTKMT2A | |
| SCHEMBL28259725 | 0.74 | TSHR (0.50) | S100A4TDP1TSHRMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012019106-A2 | POSITIVE AND NEGATIVE MODULATORS OF NMDA RECEPTORS | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2012-02-09 | — | — | WO | disclosed |