Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 1/20 | 0.59 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.59 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29898216 | 1.00 | GRIN2D (0.59) | GRIN2DGRIN2AGRIN2CPOLBCREBBP | |
| SCHEMBL569630 | 0.88 | HIPK2 (0.52) | GRIN2DGRIN2AGRIN2CPOLBCREBBP | |
| SCHEMBL7918213 | 0.78 | PLA2G2D (0.50) | GRIN2DGRIN2AGRIN2CCREBBPKDM4E | |
| SCHEMBL10081747 | 0.76 | GRIN2D (0.68) | GRIN2DGRIN2AGRIN2CKDM4EPTPN1 | |
| SCHEMBL16502635 | 0.75 | PLA2G2D (0.45) | GRIN2DGRIN2AGRIN2CCREBBPPTPN1 | |
| SCHEMBL10484184 | 0.75 | GRIN2D (0.67) | GRIN2DGRIN2AGRIN2CKDM4EPTPN1 | |
| SCHEMBL31742339 | 0.75 | GRIN2D (0.67) | GRIN2DGRIN2AGRIN2CKDM4EPTPN1 | |
| SCHEMBL15439625 | 0.75 | GRIN2D (0.67) | GRIN2DGRIN2AGRIN2CKDM4EPTPN1 | |
| SCHEMBL10148398 | 0.75 | PTPN1 (0.58) | GRIN2DGRIN2AGRIN2CCREBBPPTPN1 | |
| SCHEMBL2469905 | 0.75 | GRIN2D (0.66) | GRIN2DGRIN2AGRIN2CKDM4EPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230218638-A1 | NEUROACTIVE COMPOUNDS AND METHODS OF USE THEREOF | SAGE THERAPEUTICS, INC. | 2023-07-13 | — | — | US | disclosed |
| US-20170304321-A1 | NEUROACTIVE COMPOUNDS AND METHODS OF USE THEREOF | SAGE THERAPEUTICS INC (US) | 2017-10-26 | — | — | US | disclosed |
| WO-2016057713-A1 | NEUROACTIVE COMPOUNDS AND METHODS OF USE THEREOF | SAGE THERAPEUTICS, INC. (US) | 2016-04-14 | — | — | WO | disclosed |
| WO-2012019106-A2 | POSITIVE AND NEGATIVE MODULATORS OF NMDA RECEPTORS | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2012-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230218638-A1 | NEUROACTIVE COMPOUNDS AND METHODS OF USE THEREOF | GRIN3B, GRIN2A, GRIN1 | GRIN2D 16/4885GRIN2A 2/4885GRIN2C 7/4885 |
| US-20170304321-A1 | NEUROACTIVE COMPOUNDS AND METHODS OF USE THEREOF | GRIN3B, GRIN2A, GRIN1 | GRIN2D 16/4885GRIN2A 2/4885GRIN2C 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.