SCHEMBL10080944

SCHEMBL10080944

FC(F)(F)c1ccc(N2CCC=CCC2)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.53
CA2 P00918 1/20 0.53
CA9 Q16790 1/20 0.53
AKR1C3 P42330 1/20 0.50
DHFR P00374 1/20 0.46
NOTUM Q6P988 1/20 0.46
CYP3A4 P08684 2/20 0.45
ME2 P23368 1/20 0.44
ME1 P48163 1/20 0.44
ME3 Q16798 1/20 0.44
MLYCD O95822 1/20 0.43
DRD4 P21917 1/20 0.43
GRM2 Q14416 1/20 0.43
MAOB P27338 1/20 0.42
HRH4 Q9H3N8 1/20 0.42
HRH3 Q9Y5N1 1/20 0.42
HTR1A P08908 1/20 0.42
DRD2 P14416 1/20 0.42
HTR2A P28223 1/20 0.42
DRD3 P35462 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31506498 0.90 CA12 (0.45) CA12CA2CA9AKR1C3DHFR
SCHEMBL4072100 0.88 CA12 (0.53) CA12CA2CA9AKR1C3DHFR
SCHEMBL28650484 0.87 CA12 (0.65) CA12CA2CA9AKR1C3DHFR
SCHEMBL13285321 0.83 CA12 (0.56) CA12CA2CA9AKR1C3DHFR
SCHEMBL28842325 0.83 CA12 (0.56) CA12CA2CA9AKR1C3DHFR
SCHEMBL5153946 0.81 CA12 (0.54) CA12CA2CA9AKR1C3DHFR
Hydrochloric Acid SCHEMBL28572379 0.81 CA12 (0.54) CA12CA2CA9AKR1C3DHFR
SCHEMBL4792070 0.80 CA12 (0.49) CA12CA2CA9AKR1C3DHFR
SCHEMBL4069611 0.80 CA12 (0.46) CA12CA2CA9AKR1C3DHFR
SCHEMBL2203983 0.79 AKR1C3 (0.68) CA12CA2CA9AKR1C3DHFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012061597-A1 ALPHA-GLUCOSIDASE BINDERS AND METHODS OF THEIR USE THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTES OF HEALTH (US) 2012-05-10 WO disclosed