SCHEMBL28650484

SCHEMBL28650484

FC(F)(F)c1ccc(N2CC2)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.65
CA2 P00918 1/20 0.65
CA9 Q16790 1/20 0.65
AKR1C3 P42330 1/20 0.61
DHFR P00374 1/20 0.56
ME2 P23368 1/20 0.53
ME1 P48163 1/20 0.53
ME3 Q16798 1/20 0.53
NOTUM Q6P988 1/20 0.51
MLYCD O95822 1/20 0.51
DRD2 P14416 2/20 0.50
CYP3A4 P08684 2/20 0.50
HTR1A P08908 1/20 0.50
HTR2A P28223 1/20 0.50
DRD3 P35462 1/20 0.50
SLC6A2 P23975 2/20 0.48
SLC6A4 P31645 2/20 0.48
PHGDH O43175 1/20 0.48
MAPT P10636 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13285321 0.91 CA12 (0.56) CA12CA2CA9AKR1C3DHFR
SCHEMBL28842325 0.91 CA12 (0.56) CA12CA2CA9AKR1C3DHFR
SCHEMBL27236235 0.89 MAPT (0.62) CA12CA2CA9AKR1C3DHFR
SCHEMBL22875958 0.89 CA12 (0.56) CA12CA2CA9AKR1C3DHFR
SCHEMBL2056173 0.89 ALDH1A1 (0.57) CA12CA2CA9AKR1C3DHFR
SCHEMBL5536334 0.89 ME2 (0.66) CA12CA2CA9AKR1C3DHFR
SCHEMBL5153946 0.89 CA12 (0.54) CA12CA2CA9AKR1C3DHFR
Hydrochloric Acid SCHEMBL28572379 0.89 CA12 (0.54) CA12CA2CA9AKR1C3DHFR
SCHEMBL10080944 0.87 CA12 (0.53) CA12CA2CA9AKR1C3DHFR
SCHEMBL2203983 0.87 AKR1C3 (0.68) CA12CA2CA9AKR1C3DHFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113702452-A Method for detecting the amount of an analyte in a solution 罗伯特·博世有限公司 2021-11-26 CN disclosed