Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53BP1 | Q12888 | 2/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | NAAA | Q02083 | 4/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MLYCD | O95822 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30277616 | 0.90 | TP53BP1 (0.67) | TP53BP1SMN1; SMN2NAAAL3MBTL1GAA | |
| SCHEMBL104557 | 0.90 | TP53BP1 (0.67) | TP53BP1SMN1; SMN2NAAAL3MBTL1GAA | |
| SCHEMBL23490253 | 0.86 | TP53BP1 (0.70) | TP53BP1SMN1; SMN2L3MBTL1GAALMNA | |
| SCHEMBL18232445 | 0.86 | TP53BP1 (0.70) | TP53BP1SMN1; SMN2L3MBTL1GAALMNA | |
| SCHEMBL6535127 | 0.85 | SMN1; SMN2 (0.87) | TP53BP1SMN1; SMN2NAAAL3MBTL1GAA | |
| SCHEMBL131829 | 0.85 | SMN1; SMN2 (0.87) | TP53BP1SMN1; SMN2NAAAL3MBTL1GAA | |
| SCHEMBL21345718 | 0.84 | TP53BP1 (0.67) | TP53BP1SMN1; SMN2L3MBTL1GAANPC1 | |
| SCHEMBL104339 | 0.83 | HPGD (0.71) | TP53BP1SMN1; SMN2LMNAKMT2AHSD17B10 | |
| SCHEMBL30277542 | 0.83 | TP53BP1 (0.62) | TP53BP1SMN1; SMN2L3MBTL1GAANPC1 | |
| SCHEMBL14445019 | 0.83 | TP53BP1 (0.62) | TP53BP1SMN1; SMN2L3MBTL1GAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268999-B2 | Tri-cyclic pyrazolopyridine kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-09-18 | — | — | US | disclosed |
| US-20120053187-A1 | TRI-CYCLIC PYRAZOLOPYRIDINE KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-03-01 | — | — | US | disclosed |
| WO-2010135014-A1 | TRI-CYCLIC PYRAZOLOPYRIDINE KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-11-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053187-A1 | TRI-CYCLIC PYRAZOLOPYRIDINE KINASE INHIBITORS | PIK3CA, PIK3CD, PIK3CG | TP53BP1 1597/4885SMN1; SMN2 3180/4885NAAA 3784/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.