Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | KIF11 | P52732 | 7/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.51 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL764575 | 0.94 | TP53 (0.56) | TP53MAPTKIF11SMN1; SMN2ABCG2 | |
| SCHEMBL9961995 | 0.93 | TP53 (0.55) | TP53MAPTKIF11SMN1; SMN2ABCG2 | |
| SCHEMBL16313302 | 0.93 | KIF11 (0.55) | TP53MAPTKIF11SMN1; SMN2ABCG2 | |
| SCHEMBL12983684 | 0.93 | TP53 (0.56) | TP53MAPTKIF11SMN1; SMN2ABCG2 | |
| SCHEMBL8403122 | 0.92 | TP53 (0.56) | TP53MAPTKIF11SMN1; SMN2ABCG2 | |
| SCHEMBL8403139 | 0.91 | TP53 (0.53) | TP53MAPTKIF11SMN1; SMN2ABCG2 | |
| SCHEMBL8403669 | 0.91 | TP53 (0.54) | TP53MAPTKIF11SMN1; SMN2ABCG2 | |
| Emvododstat SCHEMBL8509210 | 0.90 | TP53 (0.62) | TP53MAPTKIF11SMN1; SMN2ABCG2 | |
| Emvododstat SCHEMBL9962251 | 0.90 | TP53 (0.62) | TP53MAPTKIF11SMN1; SMN2ABCG2 | |
| Emvododstat SCHEMBL29965534 | 0.90 | TP53 (0.62) | TP53MAPTKIF11SMN1; SMN2ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871375-B1 | CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER | PTC THERAPEUTICS INC (US) | 2012-02-29 | — | — | EP | disclosed |