Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB3 | P54753 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | DRD2 | P14416 | 4/20 | 0.51 |
| ▸ | DRD1 | P21728 | 4/20 | 0.51 |
| ▸ | DRD4 | P21917 | 4/20 | 0.51 |
| ▸ | DRD3 | P35462 | 4/20 | 0.51 |
| ▸ | HTR2A | P28223 | 3/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1682254 | 0.82 | KDM4E (0.67) | EPHB3LMNAMAPTRIPK2LCK | |
| SCHEMBL1682670 | 0.82 | KDM4E (0.55) | EPHB3LMNAALDH1A1KDM4ENPC1 | |
| SCHEMBL10086763 | 0.81 | ALDH1A1 (0.57) | LMNAMAPTALDH1A1KDM4ENPC1 | |
| SCHEMBL1682075 | 0.81 | EPHB3 (0.63) | EPHB3LMNAMAPTRIPK2LCK | |
| SCHEMBL1683507 | 0.81 | ALDH1A1 (0.56) | EPHB3LMNAMAPTALDH1A1KDM4E | |
| SCHEMBL10086760 | 0.81 | KDM4E (0.57) | EPHB3LMNARIPK2LCKALDH1A1 | |
| SCHEMBL10086758 | 0.80 | KDM4E (0.67) | EPHB3LMNAMAPTRIPK2LCK | |
| SCHEMBL1683230 | 0.77 | HCAR2 (0.54) | LMNAALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL9288081 | 0.77 | EPHB3 (0.57) | EPHB3RIPK2LCKALDH1A1KDM4E | |
| SCHEMBL9288077 | 0.77 | EPHB3 (0.57) | EPHB3RIPK2LCKALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012045729-A1 | IMIDAZO [1, 2 -A] PYRIDINE AND PYRAZOLO [1, 5 -A] PYRIDINE DERIVATIVES AS TRPV1 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2012-04-12 | — | — | WO | disclosed |