SCHEMBL10089438

SCHEMBL10089438

CCC1=C(c2cc(C)cc(CSc3ccccc3SCc3cc(C)cc(-c4c(CC)oc5ccccc45)c3O)c2O)C2C=CC=CC2O1

nearest known ligand 0.32

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 4/20 0.32
CYP2C9 P11712 3/20 0.32
EYA2 O00167 1/20 0.31
MEN1 O00255 1/20 0.31
ABCC4 O15439 1/20 0.31
PLIN1 O60240 1/20 0.31
NR1I2 O75469 1/20 0.31
USP2 O75604 1/20 0.31
ABCB11 O95342 1/20 0.31
ALDH1A1 P00352 1/20 0.31
LMNA P02545 1/20 0.31
TTR P02766 1/20 0.31
ALB P02768 1/20 0.31
ESR1 P03372 1/20 0.31
NR3C1 P04150 1/20 0.31
CYP1A2 P05177 1/20 0.31
PGR P06401 1/20 0.31
POLB P06746 1/20 0.31
CHRM2 P08172 1/20 0.31
ADRB1 P08588 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10089364 0.84 CYP2C19 (0.41) CYP2C19CYP2C9EYA2MEN1ABCC4
SCHEMBL10089359 0.74 CYP2C19 (0.42) CYP2C19CYP2C9EYA2MEN1ABCC4
SCHEMBL10089354 0.65 CYP1A2 (0.36) CYP2C19MEN1ALDH1A1LMNACYP1A2
SCHEMBL10089369 0.61 EGFR (0.39) CYP2C19CYP2C9ALDH1A1LMNACYP1A2
SCHEMBL27649528 0.60 EYA3 (0.43) CYP2C19CYP2C9EYA2MEN1ABCC4
SCHEMBL10089380 0.59 CYP2A6 (0.37) ALDH1A1MAPTHPGD
SCHEMBL28104532 0.57 CYP2C19 (0.62) CYP2C19CYP2C9EYA2MEN1ABCC4
SCHEMBL11750759 0.55 EYA3 (0.55) CYP2C19CYP2C9EYA2MEN1ABCC4
SCHEMBL15912542 0.55 HSP90AA1 (0.48) CYP2C19CYP2C9MEN1NR1I2ALDH1A1
SCHEMBL10089384 0.55 MAPT (0.38) CYP2C19ALDH1A1LMNACYP1A2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120029159-A1 POLYDENTATE HETEROATOM LIGAND CONTAINING METAL COMPLEXES, CATALYSTS AND METHODS OF MAKING AND USING THE SAME DOW GLOBAL TECHNOLOGIES LLC (US) 2012-02-02 US disclosed