EYA3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL6574630	0.48	10/20
SCHEMBL1287675	0.79	8/20
SCHEMBL3119701	0.77	8/20
SCHEMBL6336681	0.75	8/20
SCHEMBL6336499	0.73	8/20
SCHEMBL6336472	0.72	8/20
SCHEMBL1287589	0.71	8/20
SCHEMBL6737999	0.71	8/20
SCHEMBL6342546	0.70	8/20
SCHEMBL2141567	0.69	8/20
SCHEMBL6490125	0.69	8/20
SCHEMBL1287921	0.60	8/20
SCHEMBL9267705	0.55	8/20
SCHEMBL9287304	0.53	8/20
Benziodarone (SCHEMBL308541)	1.00	7/20
SCHEMBL1287450	1.00	7/20
SCHEMBL3219908	1.00	7/20
SCHEMBL1287929	0.80	7/20
SCHEMBL6336521	0.80	7/20
SCHEMBL1287413	0.79	7/20

Clinical trials — most relevant to EYA3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Safety Evaluation of Gene Therapy in Leber Hereditary Optic Neuropathy (LHON) Patients	PHASE1/PHASE2	COMPLETED
Study Evaluating Toxicity & Efficacy of Lenalidomide(Revlimid®)in Chemotherapy-Naïve AIPC Patients	PHASE2	COMPLETED
A Study of Sorafenib in Patients With Chemonaive Metastatic Uveal Melanoma	PHASE2	UNKNOWN
Safety and Efficacy of Stem Cell Small Extracellular Vesicles in Patients With Retinitis Pigmentosa	PHASE1/PHASE2	RECRUITING
Natural History Study of Patients With EYS-Associated RP	nan	RECRUITING
Rate of Progression in EYS Related Retinal Degeneration	nan	ACTIVE_NOT_RECRUITING
Investigating the Genetic Basis of Pseudoexfoliation Syndrome, Angle-closure Glaucoma and Primary Open-angle Glaucoma	nan	RECRUITING
Whole Exome and Whole Genome Sequencing for Genotyping of Inherited and Congenital Eye Conditions	nan	RECRUITING
New Biopsy Technique for Uveal Melanoma	nan	COMPLETED
Identifying Genes and Mutations Underlying Retinitis Pigmentosa and Allied Diseases	nan	UNKNOWN
Mechanisms of Inherited Retinal Dystrophies Using Whole Genome Sequencing and in Vitro and in Vivo Models	nan	COMPLETED
Validation of a Molecular Prognostic Test for Eye Melanoma	nan	WITHDRAWN
Proteomic Study of Tears From Patients With a PAX6 Mutation	nan	COMPLETED
Evolution of Visual Impairment During Pseudoxanthoma Elasticum	nan	COMPLETED
National Cohort on Congenital Defects of the Eye	nan	RECRUITING
NGS Panel of Incomplete Forms of Ocular Albinism	nan	COMPLETED
The Natural History of the Progression of Atrophy Secondary to Stargardt Disease Type 4: PROM1-Related Macular Dystrophy	nan	COMPLETED
Limbal Stem Cell Deficiency of Genetic Origin: Genotype-phenotype Correlation	nan	RECRUITING
Management of Retinitis Pigmentosa Via Electromagnetic Stimulation and Platelet Rich Plasma	nan	COMPLETED
iSITE: Investigation of Somatic Alterations in Tumours of the Eye	nan	COMPLETED
Genetic Determinant of Foveolar Hypoplasia in Parents of Albinos Children	nan	COMPLETED
Clinical and Molecular Studies in Families With Inherited Eye Disease	nan	RECRUITING
Genetic Study of Age-Related Macular Degeneration	nan	COMPLETED
Cytogenetic Study of Ocular Melanoma	nan	COMPLETED
Clinical and Genetic Analysis in Congenital Hypothyroidism Due to Thyroid Dysgenesis.	nan	COMPLETED
Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease	nan	RECRUITING
Cell Collection to Study Eye Diseases	nan	RECRUITING
Rate of Progression in USH2A-related Retinal Degeneration	nan	ACTIVE_NOT_RECRUITING
Ocular, Vascular, and Genetic Findings in AMD Patients	nan	ACTIVE_NOT_RECRUITING
Seven Year Update of Macular Degeneration Patients	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a EYA3 binder may also engage these)

Protein	Name	Similarity
Q9Z191	—	1.000	Q9Z191 →
O95677	—	1.000	O95677 →
P97767	—	1.000	P97767 →
P97480	—	1.000	P97480 →
Q90XW5	—	0.999	Q90XW5 →
Q621Z7	—	0.998	Q621Z7 →
Q5RFT9	—	0.998	Q5RFT9 →
Q96SK2	—	0.998	Q96SK2 →
Q4VYR7	—	0.998	Q4VYR7 →
Q96MY1	—	0.997	Q96MY1 →
Q9Y2X9	—	0.997	Q9Y2X9 →
Q9FNY0	—	0.997	Q9FNY0 →
Q91XT4	—	0.997	Q91XT4 →
Q700C2	—	0.997	Q700C2 →
Q8C0I4	—	0.997	Q8C0I4 →
Q6PF39	—	0.997	Q6PF39 →
Q08639	—	0.997	Q08639 →
P22199	—	0.997	P22199 →
O22921	—	0.997	O22921 →
Q1LXU5	—	0.997	Q1LXU5 →
Q9QWV9	—	0.997	Q9QWV9 →
A2RUV4	—	0.997	A2RUV4 →
Q8K0V4	—	0.996	Q8K0V4 →
Q5R9P5	—	0.996	Q5R9P5 →
Q75CK5	—	0.996	Q75CK5 →
Q9FV71	—	0.996	Q9FV71 →
A5DLJ8	—	0.996	A5DLJ8 →
Q9LYP5	—	0.996	Q9LYP5 →
O17087	—	0.996	O17087 →
Q05201	—	0.996	Q05201 →