Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 13/20 | 0.42 |
| ▸ | JAK1 | P23458 | 8/20 | 0.42 |
| ▸ | JAK3 | P52333 | 5/20 | 0.42 |
| ▸ | TYK2 | P29597 | 3/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.41 |
| ▸ | PAK4 | O96013 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.41 |
| ▸ | LTK | P29376 | 2/20 | 0.41 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.41 |
| ▸ | CLK2 | P49760 | 2/20 | 0.41 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.41 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.41 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.41 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL27929273 | 0.84 | JAK2 (0.48) | JAK2JAK1JAK3TYK2HDAC6 | |
| Trifluoroacetic Acid SCHEMBL101063 | 0.80 | JAK2 (0.64) | JAK2JAK1JAK3TYK2HDAC6 | |
| Trifluoroacetic Acid SCHEMBL29540586 | 0.76 | JAK1 (0.32) | JAK2JAK1JAK3TYK2HDAC6 | |
| Trifluoroacetic Acid SCHEMBL101065 | 0.76 | JAK1 (0.32) | JAK2JAK1JAK3TYK2HDAC6 | |
| Trifluoroacetic Acid SCHEMBL100924 | 0.76 | JAK1 (0.35) | JAK2JAK1JAK3TYK2HDAC6 | |
| Trifluoroacetic Acid SCHEMBL101064 | 0.76 | JAK1 (0.38) | JAK2JAK1JAK3TYK2HDAC6 | |
| Trifluoroacetic Acid SCHEMBL3452095 | 0.73 | JAK2 (0.33) | JAK2JAK1JAK3TYK2HDAC6 | |
| Trifluoroacetic Acid SCHEMBL101747 | 0.73 | JAK2 (0.65) | JAK2JAK1JAK3TYK2HDAC6 | |
| Trifluoroacetic Acid SCHEMBL100923 | 0.73 | DGAT1 (0.34) | JAK1 | |
| Trifluoroacetic Acid SCHEMBL99843 | 0.71 | JAK2 (0.63) | JAK2JAK1JAK3TYK2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2474545-A1 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | Incyte Corporation (US) | 2012-07-11 | — | — | EP | disclosed |
| EP-2426129-A1 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | Incyte Corporation (US) | 2012-03-07 | — | — | EP | disclosed |
| EP-2343299-A1 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | Incyte Corporation (US) | 2011-07-13 | — | — | EP | disclosed |
| EP-2343298-A1 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | Incyte Corporation (US) | 2011-07-13 | — | — | EP | disclosed |