Sugi Predict

Sugi Predict / Targets / DGAT1

DGAT1

Diacylglycerol O-acyltransferase 1 · O75907 · DGAT1 on Sugi Atlas →

95,342 patent compounds predicted against DGAT1, 37,335 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL180883 SCHEMBL180883 1.00 20/20
SCHEMBL180787 SCHEMBL180787 0.64 20/20
SCHEMBL160462 SCHEMBL160462 0.63 20/20
SCHEMBL161603 SCHEMBL161603 0.61 20/20
SCHEMBL180850 SCHEMBL180850 0.58 20/20
SCHEMBL162190 SCHEMBL162190 0.58 20/20
SCHEMBL181039 SCHEMBL181039 0.55 20/20
SCHEMBL180704 SCHEMBL180704 0.55 20/20
SCHEMBL181065 SCHEMBL181065 0.51 20/20
SCHEMBL180414 SCHEMBL180414 0.51 20/20
Pradigastat Pradigastat (SCHEMBL180536) 1.00 19/20
SCHEMBL180834 SCHEMBL180834 0.80 19/20
SCHEMBL180502 SCHEMBL180502 0.79 19/20
SCHEMBL180999 SCHEMBL180999 0.77 19/20
SCHEMBL180830 SCHEMBL180830 0.76 19/20
SCHEMBL180710 SCHEMBL180710 0.76 19/20
SCHEMBL181000 SCHEMBL181000 0.73 19/20
SCHEMBL180692 SCHEMBL180692 0.71 19/20
SCHEMBL181062 SCHEMBL181062 0.70 19/20
SCHEMBL180604 SCHEMBL180604 0.69 19/20

Clinical trials — most relevant to DGAT1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Omega 3 and Ischemic Stroke; Fish Oil as an Option PHASE4UNKNOWN
Mechanisms Underlying Metabolic Syndrome in Obesity PHASE4COMPLETED
Role of Pioglitazone in the Treatment of Non-alcoholic Steatohepatitis (NASH) PHASE4COMPLETED
Mitochondrial Oxidation and Insulin Resistance in Burn Patients Treated With Fenofibrate PHASE2/PHASE3WITHDRAWN
Vitamin E and DHA-EE on NAFLD - Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Clinical Trial (PUVENAFLD) PHASE2COMPLETED
Polyunsaturated Fatty Acids (PUFA) in Diabetic Fatty Liver PHASE2COMPLETED
Effect of Gemfibrozil on Serum Glycosylphosphatidylinositol (GPI) Phospholipase D and Triglycerides PHASE1COMPLETED
Liver Positron Emission Tomography (PET) Study of Non Alcoholic Fatty Liver Disease EARLY_PHASE1COMPLETED
Evaluation of Botanicals for Mechanisms Related to Appetite and Fat Metabolism nanCOMPLETED
A 12 Week, 3-Period Study to Evaluate the Effects of a Dietary Supplement on Lipid Metabolism nanCOMPLETED
Effect of Omega-3 Fatty Acids Supplementation on Hypertriglyceridemia in Pediatric Patients With Obesity. nanCOMPLETED
De Novo Lipogenesis in Severity of NAFLD nanCOMPLETED
Genetic Determinants:Low HDL, High Triglycerides, Obesity nanCOMPLETED
Development of Biomarker for Development of Non-Alcoholic Steatohepatitis (NASH) in Children nanWITHDRAWN
A Study on Risk Mutations of Vulnerability Genes of Schizophrenia nanUNKNOWN
Tissue Lipids and Insulin Resistance nanWITHDRAWN
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish) nanUNKNOWN
Healthy Fatty Acids in Transition nanCOMPLETED
Duality of Lipids: the Athlete's Paradox nanCOMPLETED
Lipidomic and Multi-Omics Profiling of Fatty Liver Disease in People With and Without HIV nanNOT_YET_RECRUITING
for Adipose Tissue DIabetes VAriants (fATDIVA) nanCOMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Genetic and Environmental Determinants of Triglycerides (GOLDN) nanCOMPLETED
A Longitudinal Study on Short-term Effects of Gastric Bypass on Glucose Homeostasis in Obesity nanCOMPLETED
Free Fatty Acid Induced Insulin Resistance nanCOMPLETED
Choline to Improve Malnutrition and Enhance Cognition nanRECRUITING
RCDP Natural History Study nanUNKNOWN
Role of Dairy Products in Weight Maintenance nanCOMPLETED
Effects of Fish Oils on Inflammation and Insulin Resistance nanCOMPLETED
Fish Oil and Nonalcoholic Fatty Liver Disease (NAFLD) Study nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a DGAT1 binder may also engage these)

ProteinNameSimilarity
Q9GMF1 — 1.000 Q9GMF1 →
Q8MK44 — 1.000 Q8MK44 →
Q9Z2A7 — 0.989 Q9Z2A7 →
Q9ERM3 — 0.982 Q9ERM3 →
A2VE61 — 0.953 A2VE61 →
Q99KU0 — 0.946 Q99KU0 →
Q0VCK9 — 0.944 Q0VCK9 →
Q9QZC1 — 0.944 Q9QZC1 →
P98191 — 0.943 P98191 →
Q5ZMP3 — 0.943 Q5ZMP3 →
D3ZXD8 — 0.943 D3ZXD8 →
O35052 — 0.943 O35052 →
Q9BX95 — 0.942 Q9BX95 →
Q6NYY9 — 0.941 Q6NYY9 →
E1BD52 — 0.941 E1BD52 →
Q5HZE2 — 0.941 Q5HZE2 →
A0PK00 — 0.941 A0PK00 →
Q3TA38 — 0.941 Q3TA38 →
Q9H330 — 0.941 Q9H330 →
Q91ZQ0 — 0.941 Q91ZQ0 →
Q6DD32 — 0.940 Q6DD32 →
Q5R9K4 — 0.940 Q5R9K4 →
Q6P360 — 0.940 Q6P360 →
Q91YD4 — 0.940 Q91YD4 →
A6QPF8 — 0.940 A6QPF8 →
Q8N5B7 — 0.940 Q8N5B7 →
B1AZA5 — 0.940 B1AZA5 →
Q8BXA5 — 0.940 Q8BXA5 →
Q29S14 — 0.940 Q29S14 →
TRPM2 Transient receptor potential cation channel subfamily M member 2 0.940 landscape →