Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 18/20 | 0.67 |
| ▸ | PLK3 | Q9H4B4 | 8/20 | 0.62 |
| ▸ | PLK2 | Q9NYY3 | 6/20 | 0.62 |
| ▸ | FLT3 | P36888 | 5/20 | 0.62 |
| ▸ | NEK6 | Q9HC98 | 3/20 | 0.62 |
| ▸ | TTK | P33981 | 2/20 | 0.58 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.57 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.57 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.57 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.57 |
| ▸ | MELK | Q14680 | 1/20 | 0.57 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.57 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.57 |
| ▸ | CDK2 | P24941 | 3/20 | 0.57 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.57 |
| ▸ | PIM1 | P11309 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10092916 | 0.94 | PLK1 (0.68) | PLK1PLK3PLK2FLT3NEK6 | |
| SCHEMBL525895 | 0.91 | TTK (0.69) | PLK1PLK3PLK2TTKCSNK2A2 | |
| SCHEMBL526178 | 0.90 | PLK1 (0.59) | PLK1PLK3PLK2FLT3NEK6 | |
| Potassium SCHEMBL526090 | 0.90 | TTK (0.68) | PLK1PLK3PLK2TTKCSNK2A2 | |
| SCHEMBL526088 | 0.90 | TTK (0.68) | PLK1PLK3PLK2TTKCSNK2A2 | |
| SCHEMBL10092911 | 0.89 | PLK1 (0.67) | PLK1PLK3PLK2FLT3NEK6 | |
| SCHEMBL525981 | 0.87 | TTK (0.79) | PLK1PLK3PLK2FLT3NEK6 | |
| SCHEMBL10092912 | 0.86 | PLK1 (0.68) | PLK1PLK3PLK2FLT3NEK6 | |
| SCHEMBL527318 | 0.85 | TTK (0.68) | PLK1PLK3PLK2FLT3NEK6 | |
| SCHEMBL526773 | 0.84 | PLK1 (0.76) | PLK1PLK3PLK2FLT3NEK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012013557-A1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-02 | — | — | WO | disclosed |