Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 13/20 | 0.68 |
| ▸ | PLK1 | P53350 | 7/20 | 0.53 |
| ▸ | NEK6 | Q9HC98 | 2/20 | 0.53 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.53 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.53 |
| ▸ | MELK | Q14680 | 1/20 | 0.53 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 2/20 | 0.53 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.53 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL525981 | 0.93 | TTK (0.79) | TTKPLK1NEK6CSNK2A2CSNK2B | |
| SCHEMBL10092916 | 0.85 | PLK1 (0.68) | TTKPLK1NEK6CSNK2A2CSNK2B | |
| SCHEMBL10092918 | 0.85 | PLK1 (0.67) | TTKPLK1NEK6CSNK2A2CSNK2B | |
| SCHEMBL525530 | 0.85 | TTK (0.92) | TTKPLK1PLK3PLK2 | |
| SCHEMBL526178 | 0.85 | PLK1 (0.59) | TTKPLK1NEK6CSNK2A2CSNK2B | |
| SCHEMBL526126 | 0.84 | TTK (0.79) | TTKPLK1NEK6CSNK2A2CSNK2B | |
| SCHEMBL1559108 | 0.82 | TTK (0.85) | TTKPLK1NEK6CSNK2A2CSNK2B | |
| SCHEMBL12698424 | 0.81 | TTK (1.00) | TTKPLK1PLK3PLK2 | |
| SCHEMBL526085 | 0.80 | TTK (0.82) | TTKPLK1PLK3PLK2 | |
| SCHEMBL10092911 | 0.78 | PLK1 (0.67) | TTKPLK1NEK6CSNK2A2CSNK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598508-A1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | Nerviano Medical Sciences S.r.l. (IT) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012013557-A1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-02 | — | — | WO | disclosed |