Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.30 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.30 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7750944 | 0.84 | PLK1 (0.37) | PLK1PLK3PLK2 | |
| SCHEMBL16984508 | 0.83 | OPRM1 (0.32) | PLK1PLK3PLK2 | |
| SCHEMBL14193656 | 0.75 | PLK1 (0.37) | PLK1PLK3PLK2 | |
| SCHEMBL16984420 | 0.72 | PLK1 (0.37) | PLK1PLK3PLK2 | |
| SCHEMBL16984507 | 0.71 | PLK1 (0.31) | PLK1PLK3PLK2 | |
| SCHEMBL13846078 | 0.69 | — | — | |
| SCHEMBL12856830 | 0.69 | — | — | |
| SCHEMBL10093224 | 0.69 | BRD4 (0.40) | — | |
| SCHEMBL18476409 | 0.69 | PLK1 (0.38) | PLK1PLK3PLK2 | |
| SCHEMBL18475419 | 0.69 | PLK1 (0.38) | PLK1PLK3PLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010542-B1 | 4,5-DIHYDRO-[1,2,4]TRIAZOLO[4,3-F]PTERIDINES AS PLK1 PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS | VERTEX PHARMA (US) | 2012-01-25 | — | — | EP | disclosed |