Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10094281 | 0.84 | MEN1 (0.38) | PIK3C3MEN1KMT2AHDAC8HDAC6 | |
| SCHEMBL10094266 | 0.79 | PDE10A (0.48) | PIK3C3MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL10094268 | 0.77 | HDAC8 (0.43) | MEN1KMT2AHDAC8HDAC6ALDH1A1 | |
| SCHEMBL10094267 | 0.75 | GRM4 (0.41) | PIK3C3MEN1KMT2A | |
| SCHEMBL12643789 | 0.74 | CXCR4 (0.42) | PIK3C3HDAC8HDAC6RIPK1CXCR4 | |
| SCHEMBL14213448 | 0.74 | CXCR4 (0.42) | PIK3C3HDAC8HDAC6RIPK1CXCR4 | |
| SCHEMBL2603271 | 0.74 | CXCR4 (0.42) | PIK3C3HDAC8HDAC6RIPK1CXCR4 | |
| SCHEMBL10094294 | 0.72 | TLR7 (0.41) | — | |
| SCHEMBL884681 | 0.72 | KCNA5 (0.44) | MEN1KMT2AHDAC8HDAC6NUDT1 | |
| SCHEMBL3182932 | 0.71 | CHRNB2 (0.56) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148535-B2 | Potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-04-03 | — | — | US | disclosed |
| US-8148535-B2 | Potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-04-03 | — | — | US | disclosed |
| US-20090233897-A1 | Potassium Channel Inhibitors | MERCK SHARP & DOHME CORP. | 2009-09-17 | — | — | US | disclosed |
| US-20090233897-A1 | Potassium Channel Inhibitors | MERCK SHARP & DOHME CORP. | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233897-A1 | Potassium Channel Inhibitors | KCNJ2, KCNQ2, KCNH2 | PIK3C3 4188/4885MEN1 2152/4885KMT2A 278/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.