Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 7/20 | 0.57 |
| ▸ | HSP90AB1 | P08238 | 7/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | MGAM | O43451 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | SI | P14410 | 2/20 | 0.44 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | ESRRG | P62508 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.38 |
| ▸ | TEK | Q02763 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18925230 | 0.83 | NOTUM (0.55) | HDAC1ESRRGNPC1RAB9AMEN1 | |
| SCHEMBL12229080 | 0.81 | CYP19A1 (0.56) | NPC1RAB9A | |
| SCHEMBL12194478 | 0.80 | MEN1 (0.56) | HSP90AA1HSP90AB1HDAC1NPC1RAB9A | |
| SCHEMBL23318237 | 0.80 | ESRRG (0.40) | ESRRGNPC1RAB9AEPHB4TEK | |
| SCHEMBL10094376 | 0.79 | HSP90AB1 (0.57) | HSP90AB1HDAC1ESRRGNPC1RAB9A | |
| SCHEMBL23386948 | 0.78 | CYP19A1 (0.60) | HDAC1 | |
| SCHEMBL2819423 | 0.76 | NOTUM (0.68) | HSP90AA1HSP90AB1HDAC1MGAMGAA | |
| SCHEMBL2819878 | 0.75 | TEK (0.49) | HSP90AA1HSP90AB1HDAC1EGLN1EPHB4 | |
| SCHEMBL10094377 | 0.75 | HSP90AB1 (0.62) | HSP90AB1HDAC1GAAEGLN1NPC1 | |
| SCHEMBL10094370 | 0.75 | SIGMAR1 (0.50) | HSP90AB1ESRRGMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148535-B2 | Potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-04-03 | — | — | US | disclosed |
| US-20090233897-A1 | Potassium Channel Inhibitors | MERCK SHARP & DOHME CORP. | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233897-A1 | Potassium Channel Inhibitors | KCNJ2, KCNQ2, KCNH2 | HSP90AA1 3850/4885HSP90AB1 3191/4885HDAC1 993/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.