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SIGMAR1

Sigma non-opioid intracellular receptor 1 · Q99720 · SIGMAR1 on Sugi Atlas →

579,366 patent compounds predicted against SIGMAR1, 311,922 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Fenspiride Fenspiride (SCHEMBL21016) 0.60 15/20
Clobenzorex Clobenzorex (SCHEMBL26720) 0.66 12/20
SCHEMBL8427 SCHEMBL8427 0.43 11/20
(+)-Pentazocine (+)-Pentazocine (SCHEMBL2492) 1.00 10/20
Pentazocine Pentazocine (SCHEMBL2493) 1.00 10/20
Fenalcomine Fenalcomine (SCHEMBL25623) 0.71 10/20
SCHEMBL33991 SCHEMBL33991 0.52 10/20
Dextrofemine Dextrofemine (SCHEMBL26845) 0.59 9/20
SCHEMBL12555 SCHEMBL12555 0.44 9/20
SCHEMBL21677 SCHEMBL21677 0.83 8/20
SCHEMBL2204 SCHEMBL2204 0.54 8/20
SCHEMBL12119 SCHEMBL12119 0.42 8/20
Metazocine Metazocine (SCHEMBL26347) 1.00 7/20
SCHEMBL27228 SCHEMBL27228 0.72 7/20
SCHEMBL30934 SCHEMBL30934 0.64 7/20
SCHEMBL2349 SCHEMBL2349 0.63 7/20
SCHEMBL5863 SCHEMBL5863 0.56 7/20
SCHEMBL2517 SCHEMBL2517 0.48 7/20
Dextromethorphan Dextromethorphan (SCHEMBL29949) 1.00 6/20
Levomethorphan Levomethorphan (SCHEMBL29950) 1.00 6/20

Clinical trials — most relevant to SIGMAR1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Effects of Genotype on Resting State Connectivity During Methamphetamine Administration PHASE4COMPLETED
PCA Ketamine-Morphine VS PCA Morphine as Post-Operative Analgesia in Colorectal Surgery. PHASE4COMPLETED
Morphine vs. Oxycodone for Postoperative Pain Management PHASE4COMPLETED
Intravenous Nalbuphine Versus Intravenous Dexmedetomidine for Conscious Sedation in Patients Undergoing Colonoscopy PHASE4UNKNOWN
Colonic Motor Patterns in Healthy Volunteers PHASE4COMPLETED
Anrikefon-based Patient-controlled Intravenous Analgesia Following Laparoscopic Surgery PHASE4RECRUITING
COVID-OUT: Early Outpatient Treatment for SARS-CoV-2 Infection (COVID-19) PHASE3COMPLETED
Tramadol Versus Placebo and Morphine in the Management of Post-Operative Pain Abdominoplasty PHASE3ACTIVE_NOT_RECRUITING
Tramadol Versus Placebo in the Management of Postoperative Pain Following Bunionectomy PHASE3COMPLETED
Prazosin for Alcohol Dependence and Posttraumatic Stress Disorder PHASE2COMPLETED
Acute and Short-term Effects of Cannabidiol Admin on Cue-induced Craving in Drug-abstinent Heroin Dependent Humans PHASE2COMPLETED
Genetic Effects on Dopamine Response to an Opiate PHASE2COMPLETED
Acute and Short-term Effects of CBD on Cue-induced Craving in Drug-abstinent Heroin-dependent Humans PHASE2COMPLETED
Efficacy of Fentanyl Soaked Nasal Packs on Postoperative Pain in Nasal Surgeries. PHASE2NOT_YET_RECRUITING
A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin PHASE2UNKNOWN
Efficacy of Ketamine Mouthwash in the Management of Oral and Pharyngeal Toxicity Associated With Head and Neck Chemoradiotherapy: A Phase 2, Simon 2-stage Trial PHASE2WITHDRAWN
PET/MRI in the Diagnosis of Pediatric Chronic Pain PHASE1COMPLETED
Clinical Applications of (S)-[18F]FBFP PET/CT in Healthy Volunteers and Patients With Central Nervous System Diseases PHASE1UNKNOWN
A Trial of Dextromethorphan for Treatment of Major Depressive Disorder PHASE1COMPLETED
Neuroimmune Effects of Opioid Administration PHASE1COMPLETED
Study to Test the Safety and Efficacy of Cannabidiol as a Treatment Intervention for Opioid Relapse PHASE1COMPLETED
Non-Opioid Pramipexole and Pain EARLY_PHASE1COMPLETED
Imaging CRF X NOP Interactions in Alcohol Use Disorder EARLY_PHASE1RECRUITING
RM1 Project 1 - tAN Naloxone EARLY_PHASE1RECRUITING
Medications for Opioid Use Disorder Photosensitive Retinal Ganglion Cell Function, Sleep, and Circadian Rhythms: Implications for Treatment nanRECRUITING
Effect of Intraperitoneal Bupivacaine with Dexmedotomidine or Fentanyl for Post-Operative Analgesia Following Laparoscopy in Pediatric Patients nanNOT_YET_RECRUITING
Nalbuphine Versus Fentanyl As Additives To Bupivacaine In Spinal Anaesthesia For Internal FixationI Of Tibia nanCOMPLETED
Affective Touch, Hedonia and Suicidal Behavior nanCOMPLETED
Application of Propofol Mixed With Remifentanil in Fiber Colonoscopyand Analgesia in Fiber Colonoscopy nanCOMPLETED
DNA Methylation and Perioperative Pain Treatment nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a SIGMAR1 binder may also engage these)

ProteinNameSimilarity
Q58DH7 — 1.000 Q58DH7 →
Q5PXE3 — 1.000 Q5PXE3 →
Q60492 — 1.000 Q60492 →
Q645J3 — 0.999 Q645J3 →
O55242 — 0.998 O55242 →
Q9R0C9 — 0.997 Q9R0C9 →
Q5PXE2 — 0.996 Q5PXE2 →
Q5ZL84 — 0.996 Q5ZL84 →
Q6DCU6 — 0.993 Q6DCU6 →
Q66IM1 — 0.992 Q66IM1 →
Q7ZWG9 — 0.991 Q7ZWG9 →
P32352 — 0.980 P32352 →
P87113 — 0.979 P87113 →
A2XAY1 — 0.979 A2XAY1 →
Q55BU8 — 0.978 Q55BU8 →
Q95N00 — 0.978 Q95N00 →
Q6K3D8 — 0.977 Q6K3D8 →
ERMP1 Endoplasmic reticulum metallopeptidase 1 0.976 landscape →
P49899 — 0.976 P49899 →
C4JF81 — 0.976 C4JF81 →
Q6UPR8 — 0.976 Q6UPR8 →
Q5EU90 — 0.976 Q5EU90 →
Q75EG6 — 0.976 Q75EG6 →
IL4I1 L-amino-acid oxidase 0.976 landscape →
Q9CQ04 — 0.975 Q9CQ04 →
Q3UVK0 — 0.975 Q3UVK0 →
P70551 — 0.975 P70551 →
Q5I3B2 — 0.975 Q5I3B2 →
O09046 — 0.975 O09046 →
Q90830 — 0.975 Q90830 →