Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GLP1R | P43220 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10094357 | 0.82 | MAPK1 (0.44) | SMN1; SMN2GLAMAPK1ALDH1A1L3MBTL1 | |
| SCHEMBL14818705 | 0.80 | PDE10A (0.56) | SMN1; SMN2MAPK1ALDH1A1L3MBTL1MAPT | |
| SCHEMBL14818766 | 0.77 | PDE10A (0.51) | ALDH1A1L3MBTL1MAPTPDE10AGAA | |
| SCHEMBL14818786 | 0.77 | KDM4E (0.52) | ALDH1A1L3MBTL1MAPTPDE10AGAA | |
| SCHEMBL13246643 | 0.75 | KDM4E (0.55) | SMN1; SMN2ALDH1A1L3MBTL1MAPTPDE10A | |
| SCHEMBL11491661 | 0.75 | KDM4E (0.55) | SMN1; SMN2ALDH1A1L3MBTL1MAPTPDE10A | |
| SCHEMBL7698521 | 0.73 | PDE10A (0.51) | L3MBTL1MAPTPDE10AGAAKDM4E | |
| SCHEMBL884577 | 0.71 | ALDH1A1 (0.45) | MAPK1ALDH1A1L3MBTL1MAPT | |
| SCHEMBL9417378 | 0.71 | PDE10A (0.49) | ALDH1A1L3MBTL1MAPTPDE10AGAA | |
| SCHEMBL9417382 | 0.71 | PDE10A (0.49) | ALDH1A1L3MBTL1MAPTPDE10AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148535-B2 | Potassium channel inhibitors | MERCK SHARP & DOHME CORP. (US) | 2012-04-03 | — | — | US | disclosed |
| US-20090233897-A1 | Potassium Channel Inhibitors | MERCK SHARP & DOHME CORP. | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233897-A1 | Potassium Channel Inhibitors | KCNJ2, KCNQ2, KCNH2 | SMN1; SMN2 4477/4885GLA 3825/4885MAPK1 1551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.