Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.35 |
| ▸ | PRKDC | P78527 | 4/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | HCK | P08631 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.31 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10098366 | 0.74 | RET (0.73) | RETPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL19763994 | 0.72 | RET (1.00) | RETPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL726637 | 0.69 | RET (0.76) | RETPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL726543 | 0.69 | RET (0.80) | RETPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL16075033 | 0.67 | RET (0.38) | RETPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL14475665 | 0.67 | LIMK1 (0.32) | RETPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL1598752 | 0.66 | PIK3CD (0.44) | RETPIK3CDPIK3CAPIK3CBPIK3CG | |
| Hydrochloric Acid SCHEMBL16654494 | 0.66 | PIK3CD (0.53) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL8293390 | 0.66 | RET (0.45) | RET | |
| SCHEMBL28508442 | 0.64 | RET (0.43) | RETPIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012003544-A1 | PROTEIN KINASE INHIBITORS AND METHODS OF TREATMENT | THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) | 2012-01-12 | — | — | WO | disclosed |